Andrijana Lazić

Associate Research Professor

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile:           +381 65 397 62 12                          
Phone:           +381 11 397 62 12
Fax:               +381 11 397 58 08
E-mail: andrijanak@imgge.bg.ac.rs

EDUCATION

2006 - PhD in Biochemistry,Faculty of Medicine and Surgery,University of Milan, Italy
(THESIS: “Searching for Master Gene(s) Governing Neurosecretion Competence”)
2001 - M.Sc. in Molecular Biology and Physiology, Faculty of Biology, University of Belgrade

RESEARCH EXPERIENCE

2018 - Associate Research Professor, Laboratory for Human Molecular Genetics,IMGGE, University of  Belgrade
2009 - 2018 -Assistant Research Professor, Laboratory for Human Molecular Genetics,IMGGE, University of  Belgrade
2002 - 2008 - PhD student, Laboratory for Cellular and Molecular Neurobiology, San Raffaele Scientific Institute, Milan, Italy                                              

CAREER HISTORY

2012 - Lecturer on Faculty of Biology, University of Belgrade, Course in Molecular Biology of Genes, PhD programme in Molecular Biology
2010 - 2011 - Short-term postdoctoral specialization at San Raffaele Scientific Institute, Milan Italy, as a winner of fellowship for young postdoctoral researchers organized by Serbian Ministry ofScienceandTechnological Development

OTHER ACTIVITIES

2016 - Member of the Serbian Society for Molecular Biology
2013 - Member of Serbian Neuroscience Society

RESEARCH INTEREST

The main research field is cellular and molecular neurobiology. The PhD work was focused on transcriptional repressor REST/NRSF and its role in the acquisition and maintenance of neurosecretion competence. Recent work has been focused on the studies of the regulation of expression and function of the human SOX genes. In particular, the main research interest includes SOX genes and their roles in neural differentiation.  

SELECTED PUBLICATIONS

Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro. Popović J, Klajn A, Paunesku T, Ma Q, Chen S, Lai B, Stevanović M, Woloschak GE.Cell Mol Neurobiol. 2019 Jul;39(5):619-636. doi: 10.1007/s10571-019-00667-7. https://www.ncbi.nlm.nih.gov/pubmed/30874981

Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation. Jasnic-Savovic J, Klajn A, Milivojevic M, Mojsin M, Nikcevic G. Altern Lab Anim. 2015 Mar;43(1):9-18. https://www.ncbi.nlm.nih.gov/pubmed/25802994

The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. Drakulic D, Vicentic JM, Schwirtlich M, Tosic J, Krstic A, Klajn A, Stevanovic M. An Acad Bras Cienc. 2015 Mar;87(1):389-404. https://www.ncbi.nlm.nih.gov/pubmed/25761220

SOX2 overexpression affects neural differentiation of human pluripotent NT2/D1 cells. Klajn A, Drakulic D, Tosic M, Pavkovic Z, Schwirtlich M, Stevanovic M. Biochemistry (Mosc). 2014 Nov;79(11):1172-82. https://www.ncbi.nlm.nih.gov/pubmed/25540002

Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. Popovic J, Stanisavljevic D, Schwirtlich M, Klajn A, Marjanovic J, Stevanovic M.PLoS One. 2014 Mar 17;9(3):e91852.http://www.ncbi.nlm.nih.gov/pubmed/24637840

Dual REST-dependence of L1CAM: from gene expression to alternative splicing governed by Nova2 in neural cells. Mikulak J, Negrini S, Klajn A, D'Alessandro R, Mavilio D, Meldolesi J.J Neurochem. 2012 Mar;120(5):699-709. http://www.ncbi.nlm.nih.gov/pubmed/22176577

A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells. Tomasoni R, Negrini S, Fiordaliso S, Klajn A, Tkatch T, Mondino A, Meldolesi J, D'Alessandro R. J Cell Sci. 2011 Sep 15;124(Pt 18):3174-86.http://www.ncbi.nlm.nih.gov/pubmed/21868364

Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. Popovic J, Klajn A, Petrovic I, Stevanovic M.Biochim Biophys Acta. 2010 May-Jun;1799(5-6):411-8.http://www.ncbi.nlm.nih.gov/pubmed/20074681

The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex. Klajn A, Ferrai C, Stucchi L, Prada I, Podini P, Baba T, Rocchi M, Meldolesi J, D'Alessandro R. J Neurosci. 2009 May 13;29(19):6296-307 http://www.ncbi.nlm.nih.gov/pubmed/19439607

Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF/REST. D'Alessandro R, Klajn A, Meldolesi J. Ann N Y Acad Sci. 2009 Jan;1152:194-200. http://www.ncbi.nlm.nih.gov/pubmed/

Expression of the neurosecretory process in PC12 cells is governed by REST.D'Alessandro R, Klajn A, Stucchi L, Podini P, Malosio ML, Meldolesi J. J Neurochem. 2008 May;105(4):1369-83. http://www.ncbi.nlm.nih.gov/pubmed/18298477

Non-secretory exocytoses in the brain. Cocucci E, Lorusso A, Ongania GN, Klajn A, Meldolesi J.J Physiol Paris. 2006 Mar-May;99(2-3):140-5. http://www.ncbi.nlm.nih.gov/pubmed/16426824

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