Zebrafish (Danio rerio) has become one of the most powerful model organisms in modern biomedicine. With their genetic similarity to humans, transparent embryos, and rapid development, zebrafish are ideal for studying disease mechanisms, drug toxicity, developmental biology, and regeneration. When combined with cutting-edge imaging and genetic engineering tools, zebrafish provide unique insights that connect basic science with clinical applications. We use zebrafish to model a variety of human diseases by leveraging techniques such as genetic manipulation, xenotransplantation, targeted injury, and exposure to environmental or pharmacological agents.

What We Offer

Disease Modeling

Cardiovascular diseases
Using cardiac cryoinjury models to study heart regeneration and post-injury remodeling
Cancer
Xenograft models for tumor growth, metastasis, and drug response studies, including patient-derived xenografts
Infectious diseases
Modeling bacterial and fungal infections to study host-pathogen interactions in vivo
Developmental disorders
Using transgenic lines and controlled environmental exposures to explore gene-environment interactions

Compound screening and evaluation

Pharmacological and toxicological screening - in vivo toxicity, efficacy, and bioactivity testing in zebrafish embryos and larvae

Transcriptomics

Spatial transcriptomics
Species-specific internal data pipelines for:

Annotation
Gene identification
Transcript processing

Genetic Engineering

Generation of transgenic zebrafish lines

Services

In vivo compound toxicity assessment in zebrafish embryos

Training

Practical introduction to zebrafish husbandry and basic zebrafish research techniques

Our Infrastructure

Housing and breeding systems

Fully equipped systems for maintaining up to 3000 healthy zebrafish population at all life stages, supported by custom and commercial water circulation setups to ensure optimal living conditions.

Licensed experimental animal facility

that guarantees compliance with ethical standards and regulatory requirements for safe and controlled environment for in vivo.

Advanced light microscopy platforms

For imaging and analysis, we offer high-resolution, multi-dimensional visualization of samples - from whole organisms to subcellular details. Our tools for microinjection and specimen preparation complement these imaging capabilities, facilitating complex experimental workflows.

Why Partner With Us?

We provide access to high-quality zebrafish models and specialized workflows for disease modeling, toxicological testing, transcriptomic analysis, and the generation of transgenic lines.

We offer to collaborate across academic, clinical, and industry sectors, as well as with patient associations, to ensure that our research and innovation has real-world impact.

Get in touch with our team and discover how zebrafish models can drive your research forward:

Dr. Aleksandra Divac Rankov
aleksandra.divac@imgge.bg.ac.rs
+381 66 8038500

Dr. Snežana Kojić
snezana.kojic@imgge.bg.ac.rs
+381 66 8038500