Marina Andjelkovic

Research Assistant
Laboratory for Molecular Biomedicine

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile: +381 65 397 64 45
Phone: +381 11 397 64 45
Fax: +381 11 397 58 08
E-mail: marina.andjelkovic@imgge.bg.ac.rs

EDUCATION

2019 - PhD in Molecular Biology, Faculty of Biology (FB), University of Belgrade (UB)
(Thesis: " Genomic profiling of pediatric patients with primary ciliary dyskinesia: genotype- phenotype correlation and functional characterization of novel genetic variants”.
2014 – Master of Science in Molecular biology and physiology, FB, UB
2013 - Diploma in Molecular biology and physiology, FB, UB

RESEARCH EXPERIENCE

2016 - Research Assistant, Laboratory for Molecular Biomedicine, Institute of molecular genetics and genetic engineering, UB
2014 - 2016 - Research Trainee, Laboratory for Molecular Biomedicine, IMGGE, UB.
2014 - 2015 - Participant in the project “Little school of DNAlogy” (MSTDS)
2013 - 2014 – Participant in the project Researchers night “SCIMFONICOM” (EU, CSA-SA, FP7-PEOPLE-2012-).

CAREER HISTORY

2014 - Researcher in Laboratory for Molecular Biomedicine, IMGGE, UB 

RESEARCH INTEREST

The field of my scientific interest includes pediatric pulmonary diseases, primarily primary ciliary dyskinesia (PCD). PCD is inherited in an autosomal recessive manner, and predominantly affects the respiratory tract and reproductive organs, and affects the laterality of the internal organs. Genomic profiling of patients with this disorder enabled the establishment of a precise diagnosis of PCD, but also a differential diagnosis of this disease from other pediatric lung diseases with a similar clinical presentation. Comprehensive genomic profiling enabled design of genetic algorithm which in addition to the known disease-causing genes, includes candidate genes and newly discovered genetic variants, as well as genes responsible for the individual symptoms of this disease and the genes responsible for ciliopathies, thereby improving the effectiveness of mutation detection rate and establishing a genetic diagnosis of the disease.

SELECTED PUBLICATIONS

M Andjelkovic, P Minic, M Vreca, M Stojiljkovic, A Skakic, A Sovtic, M Rodic, V Skodric-Trifunovic, N Maric, J Visekruna, V Spasovski and S Pavlovic. Genomic profiling supports the diagnosis of primary ciliary dyskinesia and reveals novel candidate genes and genetic variants. PLoS One.  2018.; 13(10):e0205422; doi: 10.1371/journal.pone.0205422.

M Anđelkovic, V Spasovski, M Vreca, A Sovtic, M Rodic, J Komazec, S Pavlovic and P Minic. The importance of genomic profiling for differential diagnosis of pediatric lung disease patients with suspected ciliopathies. Srpski arhiv za celokupno lekarstvo, 2019; doi.org/10.2298/SARH181012012A.

M Vreca, M Andjelkovic, N Tosic, A Zekovic, N Damjanov, S Pavlovic and V Spasovski. Impact of alterations in X-linked IRAK1gene and miR-146a on susceptibility and clinical manifestations in patients with systemic sclerosis. Immunology Letters, 2018; 204:1-8.

D Spasovski, V Spasovski, Z Bascarevic, M Stojiljkovic, M Vreca, M Andjelkovic and S Pavlovic. Intra-articular Injection of Autologous Adipose Derived Mesenchymal Stem Cells in Treatment of Knee Osteoarthritis. Journal of Gene Medicine, 2018; 20(1).

Skakic A, Andjelkovic M, Tosic N, Klaassen K, Djordjevic M, Pavlovic S, Stojiljkovic M. CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Gene. 2019 Apr 3;703:17-25. doi: 10.1016/j.gene.2019.04.002.

M Vreca, A Zekovic, N Damjanov, M Andjelkovic, M Ugrin, S Pavlovic and V Spasovski. Expression of TLR7, TLR9, JAK2 and STAT3 genes in peripheral blood mononuclear cells from patients with systemic sclerosis. Journal of Applied Genetics, 2018; 59(1):59-66.

Mihailo I. Stjepanovic, Violeta Mihailovic-Vucinic, Vesna Spasovski, Jelena Milin-Lazovic, Vesna Skodric-Trifunovic, Sanja Stankovic, Marina Andjelkovic, Jovana Komazec, Ana Momcilov, Milena Santric-Milicevic, Sonja Pavlovic. Genes and metabolic pathway of sarcoidosis: identification of key players and risk modifiers. Arch Med Sci. 2018. DOI: https://doi.org/10.5114/aoms.2018.79682

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