Services

HUMAN GENETICS

DNA extraction with verification	40 eur
RNA extraction with verification	40 eur

CHROMOSOMAL ABERRATIONS

Detection of numerical aberrations of chromosomes 1, 13, 18, 21, X i Y*	138 eur
Detection of microdeletion 22q11.2*	138 eur
Detection of microdeletion 15q11* (by FISH*)	138 eur

INHERITED RARE DISEASES

Clinical exome sequencing

1 250 eur

Custom analysis of a human gene

One exon

176 eur

Alpha-1 Antitrypsin Deficiency

Detection of S and Z mutations in А1АТ*

186 eur

Cystic fibrosis

Detection of F508del CFTR mutation*	127 eur
Detection of the 7 most common CFTR mutations*	294 eur
Prenatal detection of cystic fibrosis*	186 eur
Screening of the CFTR gene 2* (exons: 2,6b,8,14b,16,17a,18, 22,23,24)	931 eur
Screening of the CFTR gene 1* (exons: 1,3,4,5,6a,7,9,10, 11,12,13,14a,15,17b,19,20,21)	1323 eur

Cytochrome c oxidase deficiency

Molecular diagnosis of cytochrome c oxidase deficiency (p.Glu140Lys in SCO2 gene)

176 eur

Epidermolysis bullosa

Molecular diagnosis of dystrophic epidermolysis bullosa (c.425A>G in COL7A1)

176 eur

Familial Mediterranean fever

Molecular diagnosis of familial Mediterranean fever

176 eur

Fumarase deficiency / Reed’s syndrome

Molecular diagnosis of fumarase deficiency / Reed’s syndrome	412 eur
Molecular diagnosis of fumarase deficiency / Reed’s syndrome in a blood relative	176 eur

Gaucher disease

Molecular diagnosis of Gaucher disease	412 eur
Molecular diagnosis of Gaucher disease in a blood relative	176 eur

Glycogen storage diseases

Molecular diagnosis of glycogen storage disease type I	500 eur
Molecular diagnosis of glycogen storage disease type Ia	244 eur
Molecular diagnosis of glycogen storage disease type Ib	294 eur
Molecular diagnosis of glycogen storage disease type I in a blood relative	176 eur

MSUD (Maple syrup urine disease)

Molecular diagnosis of MSUD (Maple syrup urine disease)	588 eur
Molecular diagnosis of MSUD (Maple syrup urine disease) - BCKDHA gene	294 eur
Molecular diagnosis of MSUD (Maple syrup urine disease) - BCKDHB gene	382 eur
Molecular diagnosis of MSUD (Maple syrup urine disease) in a blood relative	176 eur

Phenylketonuria

Detection of mutations in the PAH gene

412 eur

Congenital adrenal hyperplasia

Detection of mutations, conversions and large deletions of the CYP21A2 gene	353 eur
Detection of mutations in the CYP21A2 gene - in the family member	176 eur

Shwachman-Diamond syndrome

Molecular diagnosis of Shwachman-Diamond syndrome

235 eur

Tyrosine hydroxylase deficiency

Molecular diagnosis of tyrosine hydroxylase deficiency	500 eur
Molecular diagnosis of tyrosine hydroxylase deficiency in a blood relative	176 eur

Thalassemia

Detection of mutations in β- globin genes*	235 eur
Detection of mutations in α- globin genes*	235 eur
Detection of mutations in α- and β- globin genes in the family member*	176 eur
Prenatal detection of thalassemia syndromes*	176 eur

Gilbert's syndrome

Analysis of variants of UGT1A1*28significant as a diagnostic marker in
Gilbert 's syndrome and pharmacogenetic marker during irinotecan therapy

176 eur

HEMATOLOGICAL MALIGNANCES

Quantitative detection of the BCR/ABL fusion transcript in CML and ALL	294 eur
Detection of mutations in the BCR/ABL fusion gene in patients with chronic myeloid leukemia - resistance to therapy	212 eur
Molecular detection of AML and CML and follow-up of the disease (price per sample)*	212 eur
Molecular detection of AML and CML and follow-up of the disease (price for follow-up samples)*	118 eur
Molecular detection and follow-up of minimal residual disease in ALL (price per sample)	212 eur
Molecular detection and follow-up of minimal residual disease in ALL (Price for follow-up samples)	118 eur
Determination of mutation status of rearange genes for the immunoglobulin heavy chain (IGHV) in patients with chronic lymphocytic leukemia	294 eur
The detection of the presence of t (4; 14 ) in patients with multiple myeloma	176 eur
Detection of mutations in FLT3 gene	176 eur
Detection of mutations in NPM1 gene	176 eur
Detection of V617F mutation in ЈАК2 gene*	176 eur
Detection of mutations in exons 4-10 and the flanking intronic regions of TP53 gene	249 eur
Detection of mutations in NOTCH1 gene, exon 26, 27 and 34	249 eur
Detection of mutations in MPL gene, exon 10	176 eur
Detection of mutations in CALR gene, exon 9	176 eur
Detection of mutations in c-KIT gene, exon 17	176 eur

MALE INFERTILITY

Detection of the presence of structural and numerical aberrations of sex chromosomes in infertile men (price per sample for individual analysis)	455 eur
The detection of the presence of structural and numerical aberrations of sex chromosomes in infertile men (price per sample when analyzed simultaneously 10 or more samples)	182 eur
Detection of numerical aberrations of chromosomes X, Y, 13, 18 and 21 by FISH
Detection of SRY gene on periferal blood samples	46 eur
Detection of SRY gene on amniotic fluid samples	70 eur
Detection of SRY gene on gonadal tissue samples	70 eur
Detection of DNA fragmentation in the fresh sperm samples
Detection of DNA fragmentation in the frozen sperm samples

WOMEN'S REPRODUCTIVE HEALTH

The analysis of polymorphisms A307T and N680S in the follicle-stimulating hormone receptor (FSHR) gene

THROMBOPHILIA

Thrombofilic set (FV Leiden, FII G20210A, MTHFR C677T i PAI-1 4G/5G)
Thrombofilic set – 1 mutation*	65 eur
Thrombofilic set – 2 mutations*	90 eur
Thrombofilic set – 3 mutations*	160 eur
Thrombofilic set – 4 mutations*	175 eur

PHARMACOGENETICS

Pharmacogenetics - clinical exome sequencing	1 500 eur
Detection of mutations in TPMT gene*	176 eur
Analysis of variants of UGT1А128* significant as a diagnostic marker in Gilbert 's syndrome and pharmacogenetic marker during irinotecan therapy	176 eur

NUTRIGENETICS

Genetic test for celiac disease	176 eur
Molecular detection of lactose intolerance*	127 eur
Nutrigenetics - obesity	176 eur
Nutrigenetics - caffeine, green tea and vitamin C	176 eur

GENETICS OF SPORTS

Genetics of sports - muscle power	176 eur
Genetics of sports - endurance	176 eur
Genetics of sports - tendons and ligaments	176 eur

VETERINARY

Analysis of bovine k – CASEIN gene variants	38 eur
Analysis of bovine ß – LACTOGLOBULIN gene variants	38 eur
Molecular diagnostics of BLAD (Bovine Leukocyte Adhesion Deficiency)	46 eur
Molecular diagnostics of Porcine Stress Syndrome (PSS)	46 eur

GMO TESTING

Identification of genetic modification: qualitative analysis (price per pair of primers used in the analysis)*	30 eur
Identification of genetic modification (Real-time PCR metod) price per sample*	107 eur
DNA isolation from plant material

MICROBIOLOGY

Evaluation of antimicrobial activity of materials	on request
Purchase of the reference strain	98 eur
"DNK fingerprinting" analysis microorganisms (with existing primers and reference strains)	154 eur
Identification of bacterial species by 16s rDNA sequencing a) DNA isolation b) PCR c) Sequencing d) identification	124 eur 25 eur 25 eur 66 eur 9 eur
Starter cultures for production of fermented milk products	on request
PFGE genotyping (Price is for genotyping of 1 to 20 microorganizms)	588 eur
Determining the total number of viable bacteria / yeast sample (Price is for cultivation of one bacteria in the standard medium it would be changed according to the number, type of microorganism and the needed medium)	39 eur
Molecular identification of cyanobacteria and fungi a) PCR analysis b) Sequencing c) identification	100 eur 25 eur 66 eur 9 eur
Phylogenetic analysis (up to 3 sequences) Each additional sequence	49 eur 10 eur
Determination of antifungal activity of compounds on Candida albicans ATCC 10231 strain
Determination of antibacterial activity of compounds on ESKAPE panel

TOXICOLOGY

Testing toxicity of the compound on the Zebrafish embryos in vivo

Test 1 Acute toxicity test
Test 2 Determination of teratogenic potential
Test 3 Cardiotoxicity test
Test 1+3 or 2+3

106 eur
106 eur
106 eur
139 eur

Testing cytotoxicity of the compound using the cell culture

Testing cytotoxicity of the compound using the cell culture – 1 analysis
Testing cytotoxicity of the compound using the cell culture – 2 to 3 analyses

76 eur
103 eur

COURSES

Education

Remark:
*Services accredited at the Accreditation Body of Serbia in accordance with the requirements SRPS ISO/IEC 17025:2017 (accreditation number 01-363).

Opšta pravila poslovanja

Pravila odlučivana i izjava o usaglašenosti

Quality policy

CONTACT:

Phone: + 381 64 80 44 095

E-mail: usluge@imgge.bg.ac.rs

All payments are made at the account: 160-350089-28

Services are performed by the Sector for Laboratory Investigations, which was formed on 24th January 2011 by the Institute’s Governing Board.

Sector for Laboratory Investigations performs genetic testing on the following samples:

plant material (seed, food and feed)
human biological samples (blood, bone marrow, buccal swab, amniotic fluid, chorionic villi, DNA samples, cytogenetic slides, semen)
microorganism samples
extracts and pure compounds
animal samples (blood, DNA)

Management

dr Branko Tomić, Head
dr Jelena Samardžić, Vice Head
dr Maja Stojiljkovic, Development Management