Services

In the period from 27.07.2020 to 24.08.2020. IMGGE will not provide analyzes:

1. Cystic fibrosis
2. Alpha-1 Antitrypsin Deficiency
3. Molecular detection of lactose intolerance

In the period from 10. 08. 2020. to 01.09. 2020. IMGGE will not provide services:

1. Detection of numerical aberrations of chromosomes 1, 13, 18, 21, X and Y
2. Detection of microdeletion 22q11.2
3. Detection of microdeletion 15q11
4. Detection of structural and numerical aberrations of sex chromosomes in infertile men (all types of samples)
5. Detection of numerical aberrations of chromosomes X, Y, 13, 18 and 21 in the spermatozoa by using FISH methods
6. Detection of SRY genes (all types of samples)
7. Detection of DNA fragmentation in the sperm samples (DFI index) (all types of samples)
8. The analysis of polymorphisms A307T and N680S in the follicle-stimulating hormone receptor (FSHR) gene
9. Analysis of bovine k – CASEIN gene variants
10. Analysis of bovine ß – LACTOGLOBULIN gene variants
11. Molecular diagnostics of BLAD (Bovine Leukocyte Adhesion Deficiency)
12. Molecular diagnostics of Porcine Stress Syndrome (PSS)

HUMAN GENETICS

DNA extraction with verification	40 eur
RNA extraction with verification	40 eur

CHROMOSOMAL ABERRATIONS

Detection of numerical aberrations of chromosomes 1, 13, 18, 21, X i Y*	138 eur
Detection of microdeletion 22q11.2*	138 eur
Detection of microdeletion 15q11* (by FISH*)	138 eur

INHERITED RARE DISEASES

Clinical exome sequencing

1 200 eur

Custom analysis of a human gene

One exon
5 exons
6 to 15 exons

100 eur
294 eur
588 eur

Custom analysis of a human gene (additional sample)

One exon
5 exons
6 to 15 exons

82 eur
218 eur
471 eur

Alpha-1 Antitrypsin Deficiency

Detection of S and Z mutations in А1АТ*

186 eur

Cystic fibrosis

Detection of F508del CFTR mutation*	127 eur
Detection of the 7 most common CFTR mutations*	294 eur
Prenatal detection of cystic fibrosis*	186 eur
Screening of the CFTR gene 2* (exons: 2,6b,8,14b,16,17a,18, 22,23,24)	931 eur
Screening of the CFTR gene 1* (exons: 1,3,4,5,6a,7,9,10, 11,12,13,14a,15,17b,19,20,21)	1323 eur

Cytochrome c oxidase deficiency

Molecular diagnosis of cytochrome c oxidase deficiency (p.Glu140Lys in SCO2 gene)

74 eur

Epidermolysis bullosa

Molecular diagnosis of dystrophic epidermolysis bullosa (c.425A>G in COL7A1)

74 eur

Familial Mediterranean fever

Molecular diagnosis of familial Mediterranean fever

74 eur

Fumarase deficiency / Reed’s syndrome

Molecular diagnosis of fumarase deficiency / Reed’s syndrome	391 eur
Molecular diagnosis of fumarase deficiency / Reed’s syndrome in a blood relative	74 eur

Gaucher disease

Molecular diagnosis of Gaucher disease	391 eur
Molecular diagnosis of Gaucher disease in a blood relative	74 eur

Glycogen storage diseases

Molecular diagnosis of glycogen storage disease type I	500 eur
Molecular diagnosis of glycogen storage disease type Ia	244 eur
Molecular diagnosis of glycogen storage disease type Ib	294 eur
Molecular diagnosis of glycogen storage disease type I in a blood relative	74 eur

MSUD (Maple syrup urine disease)

Molecular diagnosis of MSUD (Maple syrup urine disease)	588 eur
Molecular diagnosis of MSUD (Maple syrup urine disease) - BCKDHA gene	294 eur
Molecular diagnosis of MSUD (Maple syrup urine disease) - BCKDHB gene	382 eur
Molecular diagnosis of MSUD (Maple syrup urine disease) in a blood relative	74 eur

Phenylketonuria

Detection of mutations in the PAH gene*

380 eur

Congenital adrenal hyperplasia

Detection of mutations, conversions and large deletions of the CYP21A2 gene	224 eur
Detection of mutations in the CYP21A2 gene - in the family member	74 eur

Shwachman-Diamond syndrome

Molecular diagnosis of Shwachman-Diamond syndrome

118 eur

Tyrosine hydroxylase deficiency

Molecular diagnosis of tyrosine hydroxylase deficiency	500 eur
Molecular diagnosis of tyrosine hydroxylase deficiency in a blood relative	74 eur

Thalassemia

Detection of mutations in β- globin genes*	180 eur
Detection of mutations in α- globin genes*	140 eur
Detection of mutations in α- and β- globin genes in the family member*	75 eur
Prenatal detection of thalassemia syndromes*	75 eur

Gilbert's syndrome

Analysis of variants of UGT1A1*28significant as a diagnostic marker in
Gilbert 's syndrome and pharmacogenetic marker during irinotecan therapy

82 eur

HEMATOLOGICAL MALIGNANCES

Quantitative detection of the BCR/ABL fusion transcript in CML and ALL	260 eur
Detection of mutations in the BCR/ABL fusion gene in patients with chronic myeloid leukemia - resistance to therapy
Molecular detection of AML and CML and follow-up of the disease (price per sample)*	180 eur
Molecular detection of AML and CML and follow-up of the disease (price for follow-up samples)*	75 eur
Molecular detection and follow-up of minimal residual disease in ALL (price per sample)*	180 eur
Molecular detection and follow-up of minimal residual disease in ALL (Price for follow-up samples)*	75 eur
Determination of mutation status of rearange genes for the immunoglobulin heavy chain (IGHV) in patients with chronic lymphocytic leukemia
Molecular characterizations of IgH and TCRrearrangements	180 eur
The detection of the presence of t (4; 14 ) in patients with multiple myeloma	141 eur
Detection of mutations in FLT3 gene	135 eur
Detection of mutations in NPM1 gene	135 eur
Detection of V617F mutation in ЈАК2 gene*	135 eur

MALE INFERTILITY

Detection of the presence of structural and numerical aberrations of sex chromosomes in infertile men (price per sample for individual analysis)	455 eur
The detection of the presence of structural and numerical aberrations of sex chromosomes in infertile men (price per sample when analyzed simultaneously 10 or more samples)	182 eur
Detection of numerical aberrations of chromosomes X, Y, 13, 18 and 21 by FISH
Detection of SRY gene on periferal blood samples	46 eur
Detection of SRY gene on amniotic fluid samples	70 eur
Detection of SRY gene on gonadal tissue samples	70 eur
Detection of DNA fragmentation in the fresh sperm samples
Detection of DNA fragmentation in the frozen sperm samples

WOMEN'S REPRODUCTIVE HEALTH

The analysis of polymorphisms A307T and N680S in the follicle-stimulating hormone receptor (FSHR) gene

THROMBOPHILIA

Thrombofilic set (FV Leiden, FII G20210A, MTHFR C677T i PAI-1 4G/5G)
Thrombofilic set – 1 mutation*	65 eur
Thrombofilic set – 2 mutations*	90 eur
Thrombofilic set – 3 mutations*	160 eur
Thrombofilic set – 4 mutations*	175 eur

PHARMACOGENETICS

Detection of mutations in TPMT gene*	135 eur
Analysis of variants of UGT1А128* significant as a diagnostic marker in Gilbert 's syndrome and pharmacogenetic marker during irinotecan therapy
Detection of polymorphism in CYP2D6 gene	141 eur
Detection of polymorphism in CYP2C9 gene	41 eur
Detection of polymorphism in CYP2C19 gene	41 eur
Detection of polymorphism in NАТ2 gene	47 eur
Detection of polymorphism in CYP1А2 gene	41 eur
Detection of polymorphism in CYP3А4 gene	24 eur
Detection of polymorphism in CYP2D6, CYP2C9, CYP2C19, NAT2, CYP1A2, CYP3A4 gene	271 eur

NUTRIGENETICS

Genetic test for celiac disease	132 eur
Molecular detection of lactose intolerance*	127 eur
Detection of polymorphism in FTO gene	24 eur
Detection of polymorphism in FABP2 gene	24 eur
Detection of polymorphism in ADRB2 gene	41 eur
Detection of polymorphism in ADRB3 gene	24 eur
Detection of polymorphism in FTO, FABP2, ADRB2, ADRB3 gene	94 eur
Detection of polymorphism in АDОRА2А gene	24 eur
Detection of polymorphism in GSTM1, GSTT1 and GSTP1 genes	35 eur
Detection of polymorphism in CYP1А2, ADORA2А, АCЕ, GSTM1, GSTT1 and GSTP1 genes	82 eur

GENETICS OF SPORTS

Detection of polymorphism in ACTN3 gene	24 eur
Detection of polymorphism in АCЕ gene	24 eur
Detection of polymorphism in АМPD1 gene	24 eur
Detection of polymorphism in CK-ММ gene	24 eur
Detection of polymorphism in МLCK gene	47 eur
Detection of polymorphism in ACTN3, АCЕ, АМPD1, CK-ММ, МLCK genes	94 eur
Detection of polymorphism in PPARD gene	24 eur
Detection of polymorphism in PPARG gene	24 eur
Detection of polymorphism in VEGF gene	24 eur
Detection of polymorphism in GNB3 gene	24 eur
Detection of polymorphism in PPARа gene	24 eur
Detection of polymorphism in PPARD, PPARGc, VEGF, GNB3, PPARа genes	88 eur
Detection of polymorphism in COLIA1 gene	47 eur
Detection of polymorphism in COL5А1 gene	24 eur
Detection of polymorphism in ТNC gene	24 eur
Detection of polymorphism in COLIA1, COL5А1, ТNC genes	82 eur

VETERINARY

Analysis of bovine k – CASEIN gene variants	38 eur
Analysis of bovine ß – LACTOGLOBULIN gene variants	38 eur
Molecular diagnostics of BLAD (Bovine Leukocyte Adhesion Deficiency)	46 eur
Molecular diagnostics of Porcine Stress Syndrome (PSS)	46 eur

GMO TESTING

Identification of genetic modification: qualitative analysis (price per pair of primers used in the analysis)*	30 eur
Identification of genetic modification (Real-time PCR metod) price per sample*	107 eur
DNA isolation from plant material

MICROBIOLOGY

Purchase of the reference strain	98 eur
"DNK fingerprinting" analysis microorganisms (with existing primers and reference strains)	154 eur
Identification of bacterial species by 16s rDNA sequencing a) DNA isolation b) PCR c) Sequencing d) identification	124 eur 25 eur 25 eur 66 eur 9 eur
Starter cultures for production of fermented milk products	on request
PFGE genotyping (Price is for genotyping of 1 to 20 microorganizms)	588 eur
Determining the total number of viable bacteria / yeast sample (Price is for cultivation of one bacteria in the standard medium it would be changed according to the number, type of microorganism and the needed medium)	39 eur
Molecular identification of cyanobacteria and fungi a) PCR analysis b) Sequencing c) identification	100 eur 25 eur 66 eur 9 eur
Phylogenetic analysis (up to 3 sequences) Each additional sequence	49 eur 10 eur

TOXICOLOGY

Testing toxicity of the compound on the Zebrafish embryos in vivo

Test 1 Acute toxicity test
Test 2 Determination of teratogenic potential
Test 3 Cardiotoxicity test
Test 1+3 or 2+3

106 eur
106 eur
106 eur
139 eur

Testing cytotoxicity of the compound using the cell culture – 1 analysis

76 eur

Testing cytotoxicity of the compound using the cell culture – 2 to 3 analyses

103 eur

COURSES

Education

Remark:
*Services accredited at the Accreditation Body of Serbia in accordance with the requirements SRPS ISO/IEC 17025:2017 (accreditation number 01-363).

Impartiality and confidentiality statement

Quality policy

CONTACT:

Phone: + 381 64 80 44 095

E-mail: usluge@imgge.bg.ac.rs

All payments are made at the account: 160-350089-28

Services are performed by the Sector for Laboratory Investigations, which was formed on 24th January 2011 by the Institute’s Governing Board.

Sector for Laboratory Investigations performs genetic testing on the following samples:

plant material (seed, food and feed)
human biological samples (blood, bone marrow, buccal swab, amniotic fluid, chorionic villi, DNA samples, cytogenetic slides, semen)
microorganism samples
extracts and pure compounds
animal samples (blood, DNA)

Management

dr Branko Tomić, Head
dr Jelena Samardžić, Vice Head
dr Branka Zukic, Development Management
dr Nataša Tošić, Vice President Quality Management