Academician Milena Stevanović

Academician, Full Research Professor

Full member of Serbian Academy of Sciences and Arts
Full Professor, University of Belgrade Faculty of Biology
Full Research Professor
Institute of molecular genetics and genetic engineering (IMGGE),

University of Belgrade (UB)
Vojvode Stepe 444a, 11042 Belgrade 152, Serbia

Mobile: +381 64  8044085
Phone: +381 11 397 62 12
Fax:      +381 11 397 58 08
E-mail: milenastevanovic@imgge.bg.ac.rs 

EDUCATION

1990 -  PhD in Biological Sciences, Faculty of Biology (FB), UB
(THESIS: Structural analysis of three haplotypes of β globin gene family encoding globine chains of hemoglobin in rats Rattus Norvegicus)
1987 -  M.Sc. in Biological Sciences, FB, UB
1983 - B.Sc. in Molecular Biology, FB, University of Belgrade 

RESEARCH EXPERIENCE

2017 -  Full professor, FB, UB
2000 - Principal Research Fellow Laboratory for Human Molecular Genetics (LHMG), IMGGE, UB
1996 - 2000 - Senior Research Associate LHMG, IMGGE, UB
1991 - 1996 - Research Associate LHMG, IMGGE, UB
1988 - 1991 -  Research Assistant Genome Structure Unit (GSU), IMGGE
1986 - 1988 -  Research Trainee GSU, IMGGE 

CAREER HISTORY 

2017 - Member of National Council for Scientific Technological Development
2016 - Member of the Steering Committee of the Serbian Society for Molecular Biology
2015 - Full member of Serbian Academy of Sciences and Arts
2009 - 2015 - Associate member of Serbian Academy of Sciences and Arts
2007 -  Lecturer on FB, UB, PhD studies in Molecular biology
2007- 2016  - Member of the Scientific board for Biology, Ministry of Education, Science and Technological Development, Republic of Serbia
2005 - 2014 - Member of the Steering Committee of the Serbian Biological Society
2004 - 2006 - Member of The University Council, UB
2003 - Member of the National Committee for Bioethics of UNESCO Commission of the Republic of Serbia
2001 - 2007 - Member of Committee for Biology, Ministry of Science and Technological Development, Republic of Serbia
2001 - 2006 - President of the Scientific Council, IMGGE
1999 - Lecturer on FB, UB, Bachelor Studies, course Basic gene manipulation
1999 - Head of Laboratory for Human Molecular Genetics (LHMG), IMGGE, UB
1993 - 2010  - Member of the Board, IMGGE
1992 - 1994  - Post-doc, Genetics Department, University of Cambridge, UK
1991 - 1992  - Post-doc, Imperial Cancer Research Fund, London, UK
1986 - 1991 - Genome Structure Unit, IMGGE 

RESEARCH INTEREST

Human molecular genetics, genetic engineering, molecular phylogenetics, molecular cytogenetics. Specific scientific interest: Studying the structure and regulation of human SOX genes expression: identification of control elements involved in transcriptional regulation and analysis of the roles of Wnt and Sonic Hedgehog (SHH) signalling pathways in control of their expression; Studying the involvement of epigenetic mechanisms in the control of SOX genes expression; Investigation of the roles of SOX genes in maintaining pluripotency, cell fate determination and differentiation; Studying the roles of SOX genes in oncogenesis. High-resolution phylogenetic studies of mitochondrial DNA variation in contemporary Serbian population; Detection of micro-deletion syndromes by Fluorescent in situ Hybridization (FISH).

SELECTED PUBLICATIONS

Popovic J., Klajn A., Paunesku T., Ma Q., Chen S., Lai B., Stevanovic M., Woloschak G. Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro. Cell Mol Neurobiol. 2019. 39(5):619-636.

https://www.ncbi.nlm.nih.gov/pubmed/30874981

Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, Nikolic I, Tasic G, Raicevic S, Garros-Regulez L, Sampron N, Atkinson MJ, Anastasov N, Matheu A, Stevanovic M. SOX3 can promote the malignant behavior of glioblastoma cells. Cell Oncol (Dordr). 2018. 42(1):41-54.

https://www.ncbi.nlm.nih.gov/pubmed/30209685

Zaletel I, Schwirtlich M, Perović M, Jovanović M, Stevanović M, Kanazir S, Puškaš N. Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer's Disease Are Associated with Altered Expression of SOXB Transcription Factors. J Alzheimers Dis. 2018. 65(3):963-976.

https://www.ncbi.nlm.nih.gov/pubmed/30103323

Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja B. Benzothiazole carbamates and amides as antiproliferative species. Eur J Med Chem. 2018. 157:1096-1114.

https://www.ncbi.nlm.nih.gov/pubmed/30179747

Tosic N., Petrovic I., Grujicic N.K., Davidovic S., Virijevic M., Vukovic NS., Pavlovic S., Stevanovic M. Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia. Leuk Res. 2018. 67:32-38.

https://www.ncbi.nlm.nih.gov/pubmed/29428447

Stanisavljevic D., Petrovic I., Vukovic V., Schwirtlich M., Gredic M., Stevanovic M., Popovic J. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLoS One. 2017. 12(9):e0184686.

https://www.ncbi.nlm.nih.gov/pubmed/28926586

Topalovic V., Krstic A., Schwirtlich M., Dolfini D., Mantovani R., Stevanovic M., Mojsin M. Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. PLoS One. 2017 12(9):e0184099.

https://www.ncbi.nlm.nih.gov/pubmed/28886103

Garcia I., Aldaregia J., Marjanovic Vicentic J., Aldaz P., Moreno-Cugnon L., Torres-Bayona S., Carrasco-Garcia E., Garros-Regulez L., Egaña L,. Rubio A., Pollard S., Stevanovic M., Sampron N., Matheu A. Oncogenic activity of SOX1 in glioblastoma. Sci Rep. 2017. 7:46575.

https://www.ncbi.nlm.nih.gov/pubmed/28425506

Rakonjac M., Cuturilo G., Stevanovic M., Jelicic L., Subotic M., Jovanovic I., Drakulic D. Differences in speech and language abilities between children with 22q11.2 deletion syndrome and children with phenotypic features of 22q11.2 deletion syndrome but without microdeletion. Res Dev Disabil. 2016. 55: 322-329.

https://www.ncbi.nlm.nih.gov/pubmed/27235769

Davidovic S., Malyarchuk B., Aleksic J.M., Derenko M., Topalovic V., Litvinov A., Stevanovic M., Kovacevic-Grujicic N. Mitochondrial DNA perspective of Serbian genetic diversity. Am J Phys Anthropol 2015. 156:449-465.

http://www.ncbi.nlm.nih.gov/pubmed/25418795

Petrovic I., Milivojevic M., Popovic J., Schwirtlich M., Rankovic B., Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLoS One. 2015. 10(11):e0143591.

http://www.ncbi.nlm.nih.gov/pubmed/26588701

Popovic J., Stanisavljevic D., Schwirtlich M., Klajn A., Marjanovic J., Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. 2014. PLoS One, 9:e91852.

http://www.ncbi.nlm.nih.gov/pubmed/24637840

Popovic J., Klajn A., Petrovic I., Stevanovic M.Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. 2010. Biochim Biophys Acta: Gene Regulatory Mechanisms, 1799: 411–418.

http://www.ncbi.nlm.nih.gov/pubmed/20074681

Mojsin M., Stevanovic M. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. 2010. Biochem J, 425:107-16.

http://www.ncbi.nlm.nih.gov/pubmed/19799567

Nikčević G., Savić T., Kovačević-Grujičić N., Stevanović M. Up-regulation of the SOX3gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. 2008. J Neurochem, 107: 1206-15.

http://www.ncbi.nlm.nih.gov/pubmed/18786169

Stevanovic M. Modulation of SOX2 and SOX3 gene expression during differentiation of human neuronal precursor cell line NTERA2. 2003. Mol Biol Rep, 30: 127-132.

http://www.ncbi.nlm.nih.gov/pubmed/12841584

Stevanović M., Zuffardi O., Collignone J., Lovell-Badge R., and Goodfellow P. The cDNA sequence and chromosomal location of the human SOX2 gene. 1994. Mamm Genome, 5: 640-642.

http://www.ncbi.nlm.nih.gov/pubmed/7849401

Foster J.W., Dominguez-Steglich M.A., Guioli S., Kwok C., Weller P.A., Stevanović M., Weissenbach J., Mansour S., Young I.D., Goodfellow P.N., Brook J.D., Schafer A.J. Campomelic dysplasia and autosomal sex reversal caused by mutation in an Sry-related gene. 1994. Nature, 372: 525-530.

http://www.ncbi.nlm.nih.gov/pubmed/7990924

Stevanović M., Lovell-Badge R., Collignone J., Goodfellow, P. SOX3 is an X-linked gene related to SRY. 1993. Hum Mol Genet, 2: 2013-2018.

http://www.ncbi.nlm.nih.gov/pubmed/8111369

Farr C.J., Stevanović M., Thomson E.J., Goodfellow P., Cooke, H.J. Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis. 1992. Nat Genet, 2: 275-282.

http://www.ncbi.nlm.nih.gov/pubmed/1303279

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