Jasmina Nikodinović-Runić

Full Research Professor
Laboratory for Microbial Molecular Genetics and Ecology (LMMGE)

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade (UB)

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile:  +381 65 397 60 34
Phone:  +381 11 397 60 34
Fax:      +381 11 397 58 08
E-mail: jasmina.nikodinovic@imgge.bg.ac.rs

EDUCATION

2004 - PhD in Molecular Genetics and Biochemistry, University of New South Wales, Sydney, Australia 
(Thesis: Molecular genetics of amphotericin biosynthesis in Streptomyces nodosus)
2000 - B.Sc. in Molecular Genetics, University of Western Sydney, Sydney, Australia

RESEARCH EXPERIENCE

2014 – to date Principal Research Fellow, Laboratory for Microbial Molecular
                        Genetics and Ecology, IMGGE, UB2011 – 2014 - Senior Research Associate, LMMGE, IMGGE, UB
2006 – 2010 - Senior Research Fellow, Biocatalysis Group, University College
                       Dublin, Dublin, Ireland (www.ucd.ie)
2004 – 2006 - Postdoctoral Fellow, Department of Chemistry, University of
                       Montana, Missoula, MT, USA (www.cas.umt.edu)

ONGOING COLLABORATIONS

Prof Kevin O’Connor - University College Dublin, Ireland (www.ucd.ie)
Prof Evangelos Topakas - National Technical University of Athens, Athens, Greece (www.ntua.gr)
Prof Nigel D Priestley – University of Montana, MT, USA (www.umt.edu)
Prof Tobias Gulder – Technical University of Munich, Germany (www.tum.de)
Prof Miloš Đuran – Institute for Chemistry, Faculty of Science, University of Kragujevac, Serbia (www.kg.ac.rs)
Prof Veselin Maslak – Faculty of Chemistry, University of Belgrade, Serbia (www.chem.bg.ac.rs)Dr Radivoje Prodanovic – Faculty of Chemistry, University of Belgrade, Serbia (www.chem.bg.ac.rs)
Prof Vladimir Savic – Faculty of Pharmacy, University of Belgrade, Serbia (www.pharmacy.bg.ac.rs)
Prof Melina Kalagasidis Krušić – Faculty of Technology, University of Belgrade, Serbia (www.tmf.bg.ac.rs)

RESEARCH INTEREST

  • MICROBIAL BIOTECHNOLOGY (BACTERIAL FERMENTATIONS, STRAIN IMPROVEMENT, Streptomyces spp., Pseudomonas spp.);
  • BIOCATALYSIS (MINING FOR NOVEL BIOCATALYSTS, PROTEIN EXPRESSION and DIRECTED EVOLUTION, BIOTRANSFORMATIONS, BIOCATALYTIC PROCESS DEVELOPMENT AND OPTIMIZATION);
  • NOVEL MATERIALS (BIOPOLYMERS, POLYHYDROXYALKANOATES, NANOCELLULOSE, FUNCTIONALIZATION OF BIOPOLYMERS),
  • BACTERIAL BIOACTIVE SECONDARY METABOLITES (BIOPIGMENTS, ANTIFUNGAL and ANTICANCER COMPOUNDS)

SELECTED PUBLICATIONS

Bioactive molecules

Jovanovic, M., Radivojevic, J., O'Connor, K., Blagojevic, S., Begovic, B., Lukic, V., Nikodinovic-Runic, J., Savic, V. Rhamnolipid inspired lipopeptides effective in preventing adhesion and biofilm formation of Candida albicans. Bioorg Chem. (2019); 87, 209-217. https://www.ncbi.nlm.nih.gov/pubmed/30901676

Müller, J.I., Kusserow, K., Hertrampf, G., Pavic, A., Nikodinovic-Runic, J., Gulder, T.A.M. Synthesis and initial biological evaluation of myxocoumarin B. Org Biomol Chem. (2019);17(7):1966-1969. https://www.ncbi.nlm.nih.gov/pubmed/30357251

Pavic, A., Savic, N.D., Glisic, B.D., Crochet, A., Vojnovic, S., Kurutos, A., Stankovic, D.M., Fromm, K.M., Nikodinovic-Runic, J., Djuran, M.I. Silver(I) complexes with 4,7-phenanthroline efficient in rescuing the zebrafish embryos of lethal Candida albicans infection. J Inorg Biochem. (2019); 195, 149-163. https://www.ncbi.nlm.nih.gov/pubmed/30952084

Savić, N.D., Vojnovic, S., Glišić, B.Đ., Crochet, A., Pavic, A., Janjić, G.V., Pekmezović, M., Opsenica, I.M., Fromm, K.M., Nikodinovic-Runic, J., Djuran, M.I. Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth. Eur J Med Chem. (2018);156:760-773. https://www.ncbi.nlm.nih.gov/pubmed/30053719

Lazić J, Ajdačić V, Vojnovic S, Zlatović M, Pekmezovic M, Mogavero S, Opsenica I, Nikodinovic-Runic J. Bis-guanylhydrazones as efficient anti-Candida compounds through DNA interaction. Appl Microbiol Biotechnol. (2018);102(4):1889-1901. https://www.ncbi.nlm.nih.gov/pubmed/29330691

Radivojevic J, Skaro S, Senerovic L, Vasiljevic B, Guzik M, Kenny ST, Maslak V, O'Connor KE, Nikodinovic-Runic J. Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds. Appl Microbiol Biotechnol. (2016); 100(1):161-72. http://www.ncbi.nlm.nih.gov/pubmed/26399414

Ajdačić V, Senerovic L, Vranić M, Pekmezovic M, Arsic-Arsnijevic V, Veselinovic A, Veselinovic J, Šolaja BA, Nikodinovic-Runic J, Opsenica IM. Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates. Bioorg. Med. Chem. (2016); 24(6): 1277–91. http://www.ncbi.nlm.nih.gov/pubmed/26867487

Senerovic L, Zivkovic MD, Veselinovic A, Pavic A, Djuran MI, Rajkovic S, Nikodinovic-Runic J. Synthesis and evaluation of series of diazine-bridged dinuclear platinum(II) complexes through in vitro toxicity and molecular modeling: correlation between structure and activity of Pt(II) complexes. J. Med. Chem. (2015); 58(3):1442-51. http://www.ncbi.nlm.nih.gov/pubmed/25551180

Stankovic N, Senerovic L, Ilic-Tomic T, Vasiljevic B, Nikodinovic-Runic J. Properties and applications of undecylprodigiosin and other bacterial prodigiosins. Appl. Microbiol. Biotechnol. (2014); 98, 3841-58. http://www.ncbi.nlm.nih.gov/pubmed/24562326

O'Connor, S., Szwej, E., Nikodinovic-Runic, J., O'Connor, A., Byrne, A.T., Devocelle, M., O'Donovan, N., Gallagher, W.M., Babu, R., Kenny, S.T., Zinn, M., Zulian, Q.R., O'Connor, K.E. The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate. Biomaterials (2013); 34, 2710–18. http://www.ncbi.nlm.nih.gov/pubmed/23343631

Biocatalysis and biopolymers

Simic, S., Jeremic, S., Djokic, L., Bozic, N., Vujcic, Z., Loncar, N., Senthamaraikannan, R., Babu, R., Opsenica, I.M., Nikodinovic-Runic, J. Development of an efficient biocatalytic system based on bacterial laccase for the oxidation of selected 1,4-dihydropyridines. Enzyme Microb Technol. (2020); 132, 109411. https://www.ncbi.nlm.nih.gov/pubmed/31731971

Jeremic, S., Djokic, L., Ajdačić, V., Božinović, N., Pavlovic, V., Manojlović, D.D., Babu, R., Senthamaraikannan, R., Rojas, O., Opsenica, I., Nikodinovic-Runic, J. Production of bacterial nanocellulose (BNC) and its application as a solid support in transition metal catalysed cross-coupling reactions. Int J Biol Macromol. (2019); 129:351-360. https://www.ncbi.nlm.nih.gov/pubmed/30710586

Spasic J, Mandic M, Djokic L, Nikodinovic-Runic J. Streptomyces spp. in the biocatalysis toolbox. Appl Microbiol Biotechnol. 2018;102(8):3513-3536. https://www.ncbi.nlm.nih.gov/pubmed/29502181

Narancic T, Davis R, Nikodinovic-Runic J, O' Connor KE. Recent developments in biocatalysis beyond the laboratory. Biotechnol Lett. 2015; 37(5):943-54. http://www.ncbi.nlm.nih.gov/pubmed/25555685

Djokic L, Spasic J, Jeremic S, Vasiljevic B, Prodanovic O, Prodanovic R, Nikodinovic-Runic J. Immobilization of Escherichia coli cells expressing 4-oxalocrotonate tautomerase for improved biotransformation of β-nitrostyrene. Bioprocess Biosyst. Eng. (2015); 38(12):2389-95. http://www.ncbi.nlm.nih.gov/pubmed/26410191

Guzik MW, Kenny ST, Duane GF, Casey E, Woods T, Babu RP, Nikodinovic-Runic J, Murrey M, O’Connor K. Conversion of post consumer polyethylene to the biodegradable polymer polyhydroxyalkanoate. Appl. Microbiol. Biotechnol. (2014); 98, 4223-32. http://www.ncbi.nlm.nih.gov/pubmed/24413975

Molloy, S., Nikodinovic-Runic, J., Martin, L.B., Hartmann, H., Solano, F., Decker, H., O'Connor, K.E. Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches. Biotechnol. Bioeng. (2013); 110, 1849–57. http://www.ncbi.nlm.nih.gov/pubmed/23381872

Narancic, T., Radivojevic, J., Jovanovic, P., Francuski, D., Bigovic, M., Maslak, V., Savic, V., Vasiljevic, B., O'Connor, K.E., Nikodinovic-Runic, J. Highly efficient Michael-type addition of acetaldehyde to b-nitrostyrenes by whole resting cells of Escherichia coli expressing 4-oxalocrotonate tautomerase. Biores. Technol. (2013); 142, 462–68. http://www.ncbi.nlm.nih.gov/pubmed/23759430

Nikodinovic-Runic, J., Guzik, M., Kenny, S.T., Babu, R., Werker, A., O'Connor, K.E. Carbon-rich wastes as feedstocks for biodegradable polymer (polyhydroxyalkanoate) production using bacteria. Adv. Appl. Microbiol. (2013); 84, 139-200. http://www.ncbi.nlm.nih.gov/pubmed/23763760

Nikodinovic-Runic, J., Casey, E., Duane, G.F., Mitic, D., Hume, A.R., Kenny, S.T., O'Connor, K.E. Process analysis of the conversion of styrene to biomass and medium chain length polyhydroxyalkanoate in a two-phase bioreactor. Biotechnol. Bioeng. (2011); 108, 2447-55. http://www.ncbi.nlm.nih.gov/pubmed/21520026 

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