Anita Skakić

Assistant Research Professor
Laboratory for Molecular Biomedicine

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile:           +381 65 397 64 45                            
Phone:           +381 11 11 3976 445
Fax:               +381 11 397 58 08
E-mail:           anita.skakic@imgge.bg.ac.rs

EDUCATION

2019 - PhD in Molecular Biology, Faculty of Biology (FB), UB (Thesis: „Genomic profile of pediatric patient with hepatic glycogenosis: genotype-phenotype correlation and functional characterization of novel variants).
2013 - Diploma (equivalent to M.Sc.) in Molecular biology and physiology, module Experimental biomedicine FB, UB

RESEARCH EXPERIENCE

2020 -  “Huo-Yan” National Laboratory for Molecular Detection of Infectious Agents Belgrade
2019 - Research Associate at Laboratory for Molecular Biomedicine, IMGGE, UB
2016 - Visiting researcher at Laboratory AG Trifunovic, CECAD, University of Cologne, Germany
2015 – 2019 - Research Assistant at Laboratory for Molecular Biomedicine, IMGGE, UB
2013 – 2015 - Research Trainee at Laboratory for Molecular Biomedicine, IMGGE, UB

CAREER HISTORY

2020 – 2021 - Analysis of the synergistic effect and therapeutic potential of small molecules in patients with recurrent pulmonary infections (Innovation fond, Republic of Serbia, PoC 5269) – participant;
2019 – 2023 - European Network for Innovative Diagnosis and Treatment of Chronic Neutropenias (EuNet-INNOCHRON, funded by The European Cooperation in Science and Technology, COST ACTION 18233) – management committee substitute and core committee of Young EuNET-INNOCHRON;
2011 – 2019 - Rare diseases: Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects, (MESTD RS, III41004) – participant;
2017 – 2018 - Development of a new cell and tissue electroporator with ultrashort electrical impulses (MPNTRS, Innovation project) – participant;
2014 – 2015 - Science in motion for Friday Night commotion “SCIMFONICOM 2014-2015” (H2020-MSCA-NIGHT-2014 Researchers' night, Grant: 633376) – participant;
2013 – 2016 - Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation, SERBORDISinn”, funded by European Commission (EU-FP7-REGPOT, 316088, 2013-2016) – participant.
2013 - “Little school of DNAlogy”, grant from MESTD RS

AWARDS

2019 -The “Goran Ljubijankic” Foundation Award for the best doctoral dissertation in the field of molecular biology defended in 2019.

OTHER ACTIVITIES

Od 2021. - Member of the Sector for Technology Transfer, IMGGE (https://www.imgge.bg.ac.rs/index.php/en/innovation/ip-committee)   

RESEARCH INTEREST

The molecular basis of rare metabolic diseases (glycogen storage diseases, congenital adrenal hyperplasia), pulmonary diseases (primary ciliary dyskinesia, tuberculosis), gene editing, genotype-phenotype correlation, molecular diagnosis, stem cell therapy and targeted therapy approach.

SELECTED PUBLICATIONS

  1. The molecular basis of rare metabolic diseases (glycogen storage diseases, congenital adrenal hyperplasia), pulmonary diseases (primary ciliary dyskinesia, tuberculosis), gene editing, genotype-phenotype correlation, molecular diagnosis, stem cell therapy and targeted therapy approach.
  2. SELECTED PUBLICATIONS
  3. Anastasovska V, Kocova M, Zdraveska N, Stojiljkovic M, Skakic A, Klaassen K, Pavlovic S. A novel 9 bp deletion (c. 1271_1279delGTGCCCGCG) in exon 10 of CYP21A2 gene causing severe congenital adrenal hyperplasia. Endocrine. 2021 Mar 14. doi: 10.1007/s12020-021-02680-7.
  4. Djuric O, Andjelkovic M, Vreca M, Skakic A, Pavlovic S, Novakovic I, Jovanovic B, Skodric-Trifunovic V, Markovic-Denic Lj. Genetic variants in TNFA, LTA, TLR2 and TLR4 genes and risk of sepsis in patients with severe trauma: nested case-control study in a level-1 trauma centre in Serbia. Injury. 2021 Mar;52(3):419-425. doi: 10.1016/j.injury.2020.12.039.
  5. Sarajlija A, Djordjevic A, Kecman B, Skakic A, Pavlovic S, Pasic S, Stojiljkovic M. Impact of genotype on neutropenia in a large cohort of Serbian patients with glycogen storage disease type Ib. Eur J Med Genet. 2020;63(3):103767. doi: 10.1016/j.ejmg.2019.103767.
  6. Skakic A, Andjelkovic M, Tosic N, Klaassen K, Djordjevic M, Pavlovic S, Stojiljkovic M. CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Gene. 2019 30;703:17-25. doi: 10.1016/j.gene.2019.04.002.
  7. Andjelkovic M, Minic P, Vreca M, Stojiljkovic M, Skakic A, Sovtic A, Rodic M, Skodric-Trifunovic V, Maric N, Visekruna J, Spasovski V, Pavlovic S. Genomic profiling supports the diagnosis of primary ciliary dyskinesia and reveals novel candidate genes and genetic variants. PLoS One. 2018 9;13(10):e0205422. doi: 10.1371/journal.pone.0205422.
  8. Klaassen K, Djordjevic M, Skakic A, Desviat LR, Pavlovic S, Perez B, Stojiljkovic M. Functional Characterization of Novel Phenylalanine Hydroxylase p.Gln226Lys Mutation Revealed Its Non-responsiveness to Tetrahydrobiopterin Treatment in Hepatoma Cellular Model. Biochem Genet. 2018 13. doi: 10.1007/s10528-018-9858-5.
  9. Skakic A, Djordjevic M, Sarajlija A, Klaassen K, Tosic N, Kecman B, Ugrin M, Spasovski V, Pavlovic S, Stojiljkovic M. Genetic characterization of GSD I in Serbian population revealed unexpectedly high incidence of GSD Ib and three novel SLC37A4 variants. Clin Genet. 2018;93(2):350-355. doi: 10.1111/cge.13093.
  10. Milacic I, Barac M, Milenkovic T, Ugrin M, Klaassen K, Skakic A, Jesic M, Joksic I, Mitrovic K, Todorovic S, Vujovic S, Pavlovic S, Stojiljkovic M. Molecular genetic study of congenital adrenal hyperplasia in Serbia: novel p.Leu129Pro and p.Ser165Pro CYP21A2 gene mutations. J Endocrinol Invest. 2015 Nov;38(11):1199-210. doi: 10.1007/s40618-015-0366-8.

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