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Istraživanje
Laboratorija za molekularnu biomedicinu ima reputaciju postignutu istraživačkim rezultatima i ekpertizom u dijagnostici različitih retkih bolesti u Srbiji i na Balkanu. Napori LMB su usmereni ka istraživanjima molekularne osnove zdravlja i bolesti i translacionoj biomedicini sa ciljem da se u zdravstvenom sistemu primeni personalizovana medicina zasnovana na ličnom genomu pacijenta.
Uspešna saradnja sa brojnim istaknutim centrima i vrhunskim naučnicima iz zemalja EU rezultirala je i zajedničkim radovima, te partnerstvom u značajnim projektima. U svojim istraživanjima, LMB uspešno sarađuje sa eminentnim zdravstvenim ustanovama u Srbiji i zemljama Balkana, a stečeno znanje se primenjuje za stalno unapređenje medicinske prakse uvođenjem molekularno genetičke dijagnoze genetičkih poremećaja i maligniteta. Za mnoga genetička testiranja, LMB je jedinstveno mesto na Balkanu. Tim LMB aktivno učestvuje u obrazovanju mladih kadrova u okviru Univerziteta u Beogradu, naročito u procesu izrade multidisciplinarnih doktorskih teza. Takođe, popularizacija i promocija molekularne genetike, genomike i biomedicine na svim nivoima je stalna aktivnost istraživača Laboratorije za molekularnu biomedicinu.
Tekući projekti
- Program rada IMGGI za 2020. godinu
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, 451-03-68/2020-14/200042, 2020
Rukovodilac: Dr Jelena Begović, IMGGI
Učesnici iz IMGGI: svi zaposleni istraživači - Sinergetski učinak i terapijski potencijal malih molekula kod bolesnika sa rekurentnom plućnom infekcijom
Dokaz koncepta, Fond za inovacionu delatnost Republike Srbije, 5269, 2020-2021
Rukovodilac: dr Marina Anđelković, IMGGI
Učesnici iz IMGGI: Dr Sonja Pavlović, dr Anita Skakić, dr Vesna Spasovski, dr Kristel Klaassen - LEukaemia GENe Discovery by data sharing, mining and collaboration (LEGEND)
COST akcija CA16223, 2017-2021
Učesnici iz IMGGI: Dr Nataša Tošić, dr Sonja Pavlović - European Network for Innovative Diagnosis and Treatment of Chronic Neutropenias (EuNet-INNOCHRON)
COST akcija CA18233, 2019-2023
Učesnici iz IMGGI: Dr Sonja Pavlović, dr Anita Skakić, dr Kristel Klaassen, dr Vladimir Gašić, dr Marina Anđelković - ADHEsion GPCR Network: Research and Implementation Set the path for future Exploration (Adher'n Rise)
COST akcija CA18240, 2019-2023
Učesnici iz IMGGI: Dr Biljana Stanković, dr Nikola Kotur - Mala škola DNKlogije
Centar za promociju nauke, 2020-2021
Rukovodilac: Dr Branka Zukić, IMGGI
Učesnici iz IMGGI: Dr Sonja Pavlović, dr Milena Ugrin, dr Vesna Spasovski, dr Biljana Stanković, dr Nikola Kotur, dr Kristel Klaassen Ljubičić, dr Marina Anđelković, dr Anita Skakić, dr Vladimir Gašić, Jovana Komazec, Bojan Ristivojević - Nutrigenetika i status vitamina D, cinka i selena u srpskoj populaciji: da li smo spremni za COVID-19? - NutriCoV
Program "Pokreni se za nauku" kompanije Filip Moris, 2020-2021
Rukovodilac: Dr Nikola Kotur, IMGGI
Učesnici iz IMGGI: Dr Biljana Stanković, dr Kristel Klaassen Ljubičić, dr Anita Skakić, dr Vladimir Gašić
Odabrane publikacije
- Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment
Pavlovic S, Kotur N, Stankovic B, Zukic B, Gasic V, Dokmanovic L
Genes (Basel) 2019;10(3):E191 - CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib
Skakic A, Andjelkovic M, Tosic N, Klaassen K, Djordjevic M, Pavlovic S, Stojiljkovic M
Gene 2019;703:17-25 - Genomic profiling supports the diagnosis of primary ciliary dyskinesia and reveals novel candidate genes and genetic variants
Andjelkovic M, Minic P, Vreca M, Stojiljkovic M, Skakic A, Sovtic A, Rodic M, Skodric-Trifunovic V, Maric N, Visekruna J, Spasovski V, Pavlovic S
PLoS One 2018;13(10):e0205422 - Intra-articular injection of autologous adipose-derived mesenchymal stem cells in the treatment of knee osteoarthritis
Spasovski D, Spasovski V, Baščarević Z, Stojiljković M, Vreća M, Anđelković M, Pavlović S
J Gene Med 2018;20(1):e3002 - Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies
Viennas E, Komianou A, Mizzi C, Stojiljkovic M, Mitropoulou C, Muilu J, Vihinen M, Grypioti P, Papadaki S, Pavlidis C, Zukic B, Katsila T, van der Spek PJ, Pavlovic S, Tzimas G, Patrinos GP
Nucleic Acids Res 2017;45(D1):D846-D853 - Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease
Marjanovic I, Kostic J, Stanic B, Pejanovic N, Lucic B, Karan-Djurasevic T, Janic D, Dokmanovic L, Jankovic S, Vukovic NS, Tomin D, Perisic O, Rakocevic G, Popovic M, Pavlovic S, Tosic N
Tumour Biol 2016;37(10):13391-13401 - A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, Böhm R, Borg J, Borgiani P, Bozina N, Bruckmueller H, Burzynska B, Carracedo A, Cascorbi I, Deltas C, Dolzan V, Fenech A, Grech G, Kasiulevicius V, Kádaši Ľ, Kučinskas V, Khusnutdinova E, Loukas YL, Macek M Jr, Makukh H, Mathijssen R, Mitropoulos K, Mitropoulou C, Novelli G, Papantoni I, Pavlovic S, Saglio G, Setric J, Stojiljkovic M, Stubbs AP, Squassina A, Torres M, Turnovec M, van Schaik RH, Voskarides K, Wakil SM, Werk A, Del Zompo M, Zukic B, Katsila T, Lee MT, Motsinger-Rief A, Mc Leod HL, van der Spek PJ, Patrinos GP
PLoS One 2016;11(9):e0162866 - Gene Mutation Profiles in Primary Diffuse Large B Cell Lymphoma of Central Nervous System: Next Generation Sequencing Analyses
Todorovic Balint M, Jelicic J, Mihaljevic B, Kostic J, Stanic B, Balint B, Pejanovic N, Lucic B, Tosic N, Marjanovic I, Stojiljkovic M, Karan-Djurasevic T, Perisic O, Rakocevic G, Popovic M, Raicevic S, Bila J, Antic D, Andjelic B, Pavlovic S
Int J Mol Sci 2016;17(5):E683 - Maritime route of colonization of Europe
Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G.
Proc Natl Acad Sci U S A 2014;111(25):9211-9216 - Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
Giardine B, Borg J, Higgs D, Peterson K, Philipsen S, Maglott D, Singleton B, Anstee D, Basak AN, Clark B, Costa F, Faustino P, Fedosyuk H, Felice A, Francina A, Galanello R, Gallivan M, Georgitsi M, Gibbons R, Giordano P, Harteveld C, Hoyer J, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis M, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye J, Wiemann C, Zukic B, Chui D, Wajcman H, Hardison R, Patrinos P
Nat Genet. 2011;43(4):295-301
Kontakt
Adresa sedišta / Poštanska adresa:
Vojvode Stepe 444a,
11042 Beograd 152, Srbija
Tel: +381 11 3976445
Faks: +381 11 3975808