Goran Jovanović

Naučni savetnik

Laboratorija za molekularnu mikrobiologiju (LMM)
Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),

Univerzitet u Beogradu
Vojvode Stepe 444a, 11042 Beograd 152, Republika Srbija
Mob: +381 65 344 74 61
Tel: +381 11 397 59 60
E-mail: gjovanovic@imgge.bg.ac.rs 

OBRAZOVANJE

1997 – doktor biomedicinskih nauka, Rokfeler Univerzitet, Njujork
1990 – magistar bioloških nauka, Biološki fakultet, Univerzitet u Beogradu
1986 – diplomirani biolog, Prirodno-matematički fakultet, Univerzitet u Beogradu

ISTRAŽIVACKO ISKUSTVO

2020 - naučni savetnik, Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI), Univerzitet u Beogradu
2017-2019 – pridruženi naučni saradnik na Medicinskom fakultetu, Imperijal Koledž London
2012-2019 – naučni savetnik, Fakultet za prirodne nauke, Imperijal Koledž London
2009-2012 – unapredjeni viši naučni saradnik, Fakultet za prirodne nauke, Imperijal Koledž London
2007-2010 – viši naučni saradnik, Fakultet za prirodne nauke, Imperijal Koledž London
2004-2007 – naučni saradnik, Fakultet za prirodne nauke, Imperijal Koledž London
2004           – naučni savetnik, IMGGI, Beograd
2000-2004 – viši naučni saradnik, IMGGI, Beograd
1998-2000 – naučni saradnik, Univerzitetski medicinski centar, Univerzitet u Ženevi
1997-1998 – istrazivač saradnik, Centar za genetičko inženjerstvo (sada IMGGI), Beograd
1993-1997 – doktorand, Rokfeler Univerzitet, Njujork
1991-1993 – istraživač saradnik, Centar za genetičko inženjerstvo, Beograd
1988-1991 – istrazivač pripravnik, Centar za genetičko inženjerstvo, Beograd

PREDAVAČKO ISKUSTVO

2021-          – predavač, Biološki fakultet, Univerzitet u Beogradu
2012-2019 – predavač, Fakultet za prirodne nauke, Imperijal Koledž Londo
2007           – gostujući predavač, Biološki fakultet, Univerzitet u Beogradu
2000-2004 – docent, Biološki fakultet, Univerzitet u Beogradu
1997-1998 – docent, Biološki fakultet, Univerzitet u Beogradu
1989-1993 – asistent, Biološki fakultet, Univerzitet u Beogradu

RADNO ISKUSTVO

2012-2019 – rukovodilac naučne grupe za Biologiju membrane, Fakultet za prirodne nauke, Imperijal Koledž London
2013-2017 – laboratorijski redar za sigurnost i zaštitu na radu, Imperijal Koledž London
2001-2004 – zamenik predsednika Naučnog Veća, Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI), Beograd
2000-2004 – zamenik rukovodioca Laboratorije za molekularnu genetiku industrijskih mikroorganizama, IMGGI, Beograd
2000-2004 – glavni redar za sigurnost i zaštitu na radu u IMGGI, Beograd   

OBLAST NAUČNOG INTERESOVANJA

Molekularna mikrobiologija; Molekularna genetika, biohemija i fiziologija mikroorganizama; Regulacja ekspresije gena u bakterijama; Ćelijska biologija odgovora na stres membrane; Signali i prenos signala membranskog stresa; Izučavanje interakcija proteina sa membranom; mikroskopija živih bakterija na nivou jednog molekula; Izučavanje prostorno-vremenske organizacije odgovora na stress; Evolucija kontrole stresa membrane; Regulatorne mreže i sistemska biologija kod bakterija; Evolucija promotora i regulacije gena; Izučavanje molekularnih mehanizama rezistencije na antibiotike kod solitarnih i intraćelijskih bakterija; Molekularna genetika bakteriofaga; Razvoj novih antimikrobnih peptida.

ODABRANI NAUČNI RADOVI (od 2004)

Engl C., G. Jovanovic, R. Brackston, I. Kotta-Loizou, M. Buck. (2020) The Route to Transcription Initiation Determines the Mode of Transcriptional Bursting in Bacteria. Nature Communications, 11:2422.

McDonald C., G. Jovanovic G., B. A. Wallace, O. Ces, M. Buck. (2017) Structure and Function of PspA and Vipp1 N-terminal Peptides: Insights into the Membrane Stress Sensing and Mitigation. Biochimica et Biophysica Acta (BBA) - Biomembranes, (1859): 28-39.

McDonald C., G. Jovanovic, O. Ces, M. Buck. (2015) Membrane Stored Curvature Elastic Stress Modulates Recruitment of Maintenance Proteins PspA and Vipp1. mBio, 6:e01188-15.

Jovanovic G., P. Mehta, L. Ying, M. Buck. (2014) The Anionic Lipids and Cytoskeletal Proteins MreB and RodZ Define the Spatial Distribution and Functioning of Membrane Stress Controller PspA in Escherichia coli. Microbiology (SGM), 160:2374-2386. (Editor’s Choice)

Jovanovic G., P. Mehta, C. McDonald, A. Davidson, P. Uzdavinys, L Ying, M. Buck. (2014) The N-terminal Amphipathic Helices Determine Regulatory and Effector Functions of Phage Shock Protein A (PspA) in Escherichia coli. Journal of Molecular Biology, 426:1498-1511. 

Mehta P., G. Jovanovic, T. Lenn, A. Bruckbauer, C. Engl, L. Ying, M. Buck. (2013) Dynamics and Stoichiometry of a Regulated Enhancer-Binding Protein in Live Escherichia coli Cells. Nature Communications, 4:1997.

Huvet M., T. Toni, X. Sheng, T. W. Thorne, G. Jovanovic, C. Engl, M. Buck, J. W. Pinney, M. P. H. Stumpf. (2011) The evolution of the Phage shock protein response system: interplay between protein function, genomic organization and system function. Molecular Biology and Evolution, 28:1141-1155.

Lenn T., C. N. Gkekas, L. Bernard, C. Engl, G. Jovanovic, M. Buck, L. Ying. (2011) Measuring the Stoichiometry of Functional PspA Complexes in Living Bacterial Cells by Single Molecule Photobleaching. Chemical Communications, 47:400-402.

Jovanovic G., C. Engl, A. Mayhew, P. C. Burrows, M. Buck. (2010) Phage Shock Protein (Psp) Inner Membrane Regulatory Complexes Govern Signal Transduction and Induction of the Psp Response in Escherichia coli. Microbiology (SGM), 156:2920-2932.

Joly N., C. Engl, G. Jovanovic, M. Huvet, T. Toni, X. Sheng, M. P. H. Stumpf, M. Buck. (2010) Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanism to physiology. FEMS Microbiology Reviews, 34:797-827.

Joly N., P. C. Burrows, C. Engl, G. Jovanovic, M. Buck. (2009) A Lower Order Form of the Phage Shock Protein A (PspA) Stably Associates with the Hexameric AAA+ Transcription Activator Protein PspF for Negative Regulation. Journal of Molecular Biology, 394:764-775.

Jovanovic G., C. Engl, M. Buck. (2009) Physical, Functional and Conditional Interactions between ArcAB and Phage Shock Proteins Upon Secretin-Induced Stress in Escherichia coli. Molecular Microbiology, 74:16-28.

Engl C., G. Jovanovic, L. J. Lloyd, H. Murray, M. Spitaler, L. Ying, J. Errington, M. Buck. (2009) In vivo Localisations of Membrane Stress Controllers PspA and PspG in Escherichia coli. Molecular Microbiology, 73:382-396.

Jovanovic G., L. J. Lloyd, M. P. H. Stumpf, A. Mayhew, M. Buck. (2006) Induction and Function of the Extracitoplasmic Stress Phage Shock Protein (Psp) Response in Escherichia coli. Journal of Biological Chemistry, 281:21147-21161.

Lloyd L. J., S. E. Jones, G. Jovanovic, P. Gyaneshwar, M. D. Rolfe, A. Thompson, J. C. Hinton, and M. Buck. (2004) Identification of a New Member and Effector of the Phage Shock Protein Response in Escherichia coli, Phage Shock Protein G (PspG). Journal of Biological Chemistry, (279): 55707-55714.

ODABRANE KNJIGE

Zhang N., G. Jovanovic, C. McDonald, O. Ces, X. Zhang, M. Buck. (2016) Transcripiton Regulation and Membrane Stress Management in Enterobacterial Pathogens. Book Chapter In Biophysics of Infection, Series: Advances in Experimental Medicine and Biology (AEMB), Vol. 915, Chapter 13, p. 207-230, M. Leake (Ed.), Hardcover ISBN: 978-3-319-32187-5, DOI: 10.1007/978-3-319-32189_13, ©Springer International Publishing Switzerland.

Jovanovic G., P. Mehta, C. McDonald, M. Buck. (2015) Promoter Order Strategy and Bacterial PspF Regulon Evolution. Book Chapter In Evolutionary Biology: Biodiversification from Genotype to Phenotype, Chapter 14, p. 263-283, P. Pontarotti (Ed.), Hardcover ISBN: 978-3-319-19931-3, eBook ISBN: 978-3-319-19932-0, ©Springer International Publishing Switzerland.

Buck M., C. Engl, N. Joly, G. Jovanovic, M. Jovanovic, E. Lawton, C. McDonald, J. Schumacher, C. Waite, N. Zhang. (2015) In vitro and in vivo Methodologies for Studying the Sigma54-Dependent Transcription.  Book Chapter In Bacterial Transcriptional Control, Methods and Protocols, Series: Methods in Molecular Biology, ISSN: 1064-3745, Vol. 1276, Chapter 4, p. 53-79, I. Artsimovitch and T. J. Santangelo (Eds.), Hardcover ISBN: 978-1-4939-2391-5, eBook ISBN: 978-1-4939-2392-2, ©Humana Press, a part of Springer Science (Springer Protocols) + Business Media, LLC.

PATENTI

Beekwilder J., J. Rakonjac, D. Bosch, M. Jongsma, W. Stiekema, G. Jovanovic. Phagemids: Phagemid Vector: psp-gIII Phage Display Vector. Patent - United States Letters Patent, U.S. patent number US 6,333,187 B1, Issue date 12/25/2001. Company: Plant Bioscience Limited, UK, 2003. 

Beekwilder J., J. Rakonjac, D. Bosch, M. Jongsma, W. Stiekema, G. Jovanovic. Collection of Phagemids, and a Collection of E. coli Cells Carrying the Phagemids. US Patent 6,333,187, A1, Issue date 12/25/2001. Company: Plant Bioscience Limited, UK, 2003.

Rakonjac J., G. Jovanovic. A Collection of Phagemids, and a Collection of E. coli Cells Carrying the Phagemids. Patent - EP 0.699.750, Issue date 06/23/1999. Company: Selective Genetics - 09/163,540, U.S.A., 1999.

TEZE

Jovanovic G. Activation of Phage Shock Protein Operon Transcription in Escherichia coli. Ph.D. Thesis. The Rockefeller University, New York, 1997. 

Jovanovic G. Homologous Recombination of Chromosomal Insertion Sequences as a Mode of Regulation of Gene Expression in Escherichia coli K12. Master (M.Sc.) Thesis, Faculty of Biology, University of Belgrade, Belgrade, 1990.

Citiranost: Science Citation Index SCIGoogle Scholar: Citati 2038/poslednjih 5 godina 754; h-indeks 24/17; i10-indeks 32/28. – ResearchGate: Citati 1575; h-indeks 22 (bez autocitata h-indeks 19); Naučni interes 841.5; Čitanost publikacija 5418; RG skor 32.21.

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