Tatjana Kostić

Assistant Research

Laboratory for Biomedicine
Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile:  +381 65  397 64 45                         
Phone:  +381 11 397 64 45
Fax:      +381 11 397 58 08
E-mail: tatjana.kostic@imgge.bg.ac.rs

EDUCATION

2001 - PhD in Molecular Genetics and Genetic Engineering, Faculty of Biology (FB), UB
(Molecular basis of genetic rearrangements induced by IS5 elements in polA1 mutator strain of Escherichia coli K12)
1990 - M.Sc. in Molecular Genetics and Genetic Engineering, FB, UB
1985 - B.Sc. in Biology, FB, University of Belgrade

RESEARCH EXPERIENCE

2017-  Research Associete, IMGGE
2011-  Research  Associete, IMGGE
2007 - Researcher, IMGGE
2001-  Research Associate, IMGGE
1990 - Research Assistant , IMGGE
1986 - Research  Assistant, IMGGE

CAREER HISTORY

2013 – Laboratory for Biomedicine, IMGGE
2003 -2013 Laboratory for Molecular Hematology, IMGGE
2003 - ICGEB Fellowship  (Trieste, Italy),Hospital «Burlo Garrofolo», Dpto. for Medical Genetics
2000 – 2002  Laboratory for Genetic Engineering of Microorganism
1999 -2000  Guest scientist, University of Cordoba, Spain (Dpto.de Bioqimica y Biologia Molecular)   
1996-1999  Laboratory  for Molecular Genetics of Procaryota, IMGGE     
1994 -1996 Fellowship from Spanich Ministry for Science and Education, Project of EU, (Dpto.de Bioquimica y Biologia Molecular, Universidad de Cordoba)
1986-1993 Laboratory for Molecular Genetics of Procaryota

SELECTED PROJECTS

1.Rare diseases: Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects (integrative and interdisciplinary research project, No. III 41004), Ministry of Science and Technological Development, Republic of Serbia, 2011-2019.

2.Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation (SERBORDISinn), EU FP7-REGPOT-2012-2013-1, European Commission, 2013-2016.

3.Short course of DNAlogy (science popularisation project), Center for Popularization of         Science, Republic of Serbia, 2009- 2011.

4.Health improvement in Serbia trough reinforcement of biomedical science and technology “HISERBS” (SSA, FP6-INCO-026357), European Commission, 2006-2009.

5.Coding and non-coding sequences of DNA (03E12, 1996-2000), Ministry of Science and Technology, Republic of Serbia

6.Project of EU: “Development of new procedures for the detection of genetic alterations in man” (EV-CT91-0004, STEP-CT91-0147, 1994-1996), Spain

7.Project of Spanich Ministry of Science and Technology „RSM mutagenesis“ (Programa Nacional de la Salud, 1994-1995), Spain

8.Project of National Institute of Health (NIH), USA (JBP615; 02-112-N) „PolA1 mutants a powerful mutators“, 1986-1990, 1990-1993.

RESEARCH INTEREST

Molecular genetics of rare disease, hematological malignancies (molecular markers of childhood and adult acute and chronic myeloid and lymphoid leukemias, lymphomas and multiple myelomas), molecular mechanisms of replication, recombination and reparation in a process of mutagenesis and carcinogenesis, quantification of mutations, genotype-phenotype correlation, autoimmunity, metabolic disease (Gaucher disease),population genetics.    

Molecular-genetic diagnostics is introduced in a meny therapeutic protocols.

TEACHING ACTIVITIES

Cours of Molecular genetics of procariota, Faculty of Biology (1997, 1998) 

SELECTED PUBLICATIONS

1.Marjanovic I, Karan Djurasevic T, Kostic T, Virijevic M, Suvajdzic Vukovic N, Pavlovic S, Tosic N. Prognostic significance of combined BAALC and MN1 gene expression level in acute myeloid leukemia with normal karyotype. International Journal of Laboratory Hematology (2020). DOI: 10.1111/ijlh.13405 

2.Vukovic V, Karan-Djurasevic T, Antic D, Tosic N, Kostic T, Marjanovic I, Dencic-Fekete M, Djurasinovic V, Pavlovic S, Mihaljevic B. Association of SLC28A3 Gene Expression and CYP2B6*6 Allele with the Response to Fludarabine Plus Cyclophosphamide in Chronic Lymphocytic Leukemia Patients. Pathol Oncol Res. (2020); 26:743-752. doi: 10.1007/s12253-019-00613-4. 

3.Janic D, Peric J, Karan-Djurasevic T, Kostic T, Marjanovic I, Stanic B, Pejanovic N, Dokmanovic L, Lazic J, Krstovski N, Virijevic M, Tomin D, Vidovic A, Suvajdzic Vukovic N, Pavlovic S, Tosic N. Application of targeted next generation sequencing for the mutational profiling of patients with acute lymphoblastic leukemia.. J Med Biochem (2020); 39(1):72-82. DOI: 10.2478/jomb-2019-0017.

4.Mitrovic M, Kostic T, Virijevic M, Karan-Djurasevic T, Suvajdzic Vukovic N, Pavlovic S, Tosic N. The influence of Wilms' tumor 1 gene expression level on prognosis and risk stratification of acute promyelocytic leukemia patients. Int J Lab Hematol (2020); 42(1):82-87. doi: 10.1111/ijlh.13144. 

5.Marjanovic I, Karan-Djurasevic T, Kostic T, Virijevic M, Suvajdzic-Vukovic N, Pavlovic S, Tosic N. Expression pattern and prognostic significance of EVI1 gene in adult acute myeloid leukemia patients with normal karyotype. Indian J Hematol Blood Transfus (2020); 30(2):292-299.. doi: 10.1007/s12288-019-01227-1.

6.Vukovic V, Karan-Djurasevic T, Antic D, Tosic N, Kostic T, Marjanovic I, Dencic-Fekete M, Djurasinovic V, Pavlovic S, Mihaljevic B. Association of SLC28A3 Gene Expression and CYP2B6*6 Allele with the Response to Fludarabine Plus Cyclophosphamide in Chronic Lymphocytic Leukemia Patients. Pathol Oncol Res. 2019 Feb 18. doi: 10.1007/s12253-019-00613-4. [Epub ahead of print]

7.Janic D, Peric J, Karan-Djurasevic T, Kostic T, Marjanovic I, Stanic B, Pejanovic N, Dokmanovic L, Lazic J, Krstovski N, Virijevic M, Tomin D, Vidovic A, Suvajdzic Vukovic N, Pavlovic S, Tosic N. Application of targeted next generation sequencing for the mutational profiling of patients with acute lymphoblastic leukemia.. J Med Biochem 2019; 38: 1–11,. DOI: 10.2478/jomb-2019-0017

8.Mitrovic M, Kostic T, Virijevic M, Karan-Djurasevic T, Suvajdzic Vukovic N, Pavlovic S, Tosic N. The influence of Wilms' tumor 1 gene expression level on prognosis and risk stratification of acute promyelocytic leukemia patients. Int J Lab Hematol. 2019 Dec 12. doi: 10.1111/ijlh.13144. [Epub ahead of print]

9.Rodić P, Lakočević M, Pavlović S, Đurašević TK, Kostić T, Vuković NS, Šumarac Z, Petakov M, Janić D. Immunoglobulin Heavy Chain Gene Rearrangements in Patients with Gaucher Disease. J Med Biochem. 2018 Jul 1;37(3):307-312.

10. Ksenija Vučićević, Vladimir Jakovljević, Nataša Čolović, Nataša Tošić, Tatjana Kostić, Irena Glumac, Sonja Pavlović, Teodora Karan Djurašević, Milica Čolović: Expression of Bcl2 Gene in Chronic lymphocytic leukemia patients. Serbian Journal of Experimental Clinical Research. 2015, 187-191               

 11. Rodić P, Pavlović S, Kostić T, Suvajdžić Vuković N, Djordjević M, Šumarac Z, Dajak M, Bonaci Nikolić B, Janić D.  (2013) Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. Blood Cells Mol Dis. 50: 222-225 

12. Karan-Djurašević T, Palibrk V, Kostić T, Spasovski V, Nikčević G, Srzentić S, Čolović M, Čolović N, Vidović A, Antić D, Mihaljević B, Pavlović S, Tošić N. (2012). Mutational Status and gene repertoire of IGHV-IGHD-IGHJ rearrangements in Serbian patients with chronic lympfocytic leukemia. Clin lymphoma myeloma Leuk. 12(4): 252-60

 13. Bakrač, M; Juršić, V; Kostić, T; Popović, V; Pekić, S; Kraguljac, N; Čolović, M.   Pure red cell aplasia associated with type I autoimmune polyglandular syndrome-successful response to treatment with mycophenolate mofetil (2007). J.ClinPathol, vol.60 br.6, 717-720. 

14. H. Steingrimsdottir, D. Beare, J. Cole, J.F.M. Leal, T. Kostić, J. Lopez-Barea, G. Dorado, A.R. Lehman, (1996). Development of new molecular procedures for the detection of genetic alterations in man. Mutation Research, 353: 109-121.

15. Jovanović G., T. Kostić, M. Janković and D. Savić, (1994). Nucleotide sequence of the Escherichia coli  K-12 histidine operon revisited. J.Mol.Biol., 239: 433-435.

16. Janković, M., T. Kostić and D.Savić, (1990). DNA sequence analysis of spontaneus histidine mutation in polA1 strain of Escherichia coli  K-12 suggests a specific role of the GTGG sequenc. Molecular & General Genetics 223: 481-486.

17. Jovanović G., T. Kostić and D. Savić, (1990). Nucleotide and amino acid polymorphism in the gene for L-histidinol dehidrogenase of Escherichia coli  K-12. Nucl. Acids Res., 18: 33634.

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