Molecular characterization of immunoglobulin (IgH) and T-cell receptor (TCR) gene rearrangements

Lymphoproliferative diseases diagnosis is based on histochemistry and immunophenotypic features, but sometimes it is difficult to discriminate the malignant clone. The presence of clonality is a basic feature of any malignancy and therefore it is the basis of molecular genetic diagnosis of lymphoproliferative disease, where there is an expansion of malignantly transformed clone. Material used for detection of IgH and TCR rearrangements is obtained by isolating DNA from the whole peripheral blood and using appropriated PCR programs. Clonality of B or T cells is analyzed using characterization of clone-specific gene rearrangements of immunoglobulin heavy chain (IgH) or of the T cell receptor (TCR).

It is necessary to deliver 10 ml of peripheral blood using 3.8% sodium citrate as anticoagulant in vol/vol ratio 9:1. The sample is required to be delivered fresh, without freezing, during the same day. The samples are accepted every day from 10 to 13h. It is possible to deliver the sample via post express service. The analysis is performed within 10 working days. The results and the bill are sent to the patient's home address, or can be collected personally at the Institute from 10 to 16h every day.

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  • dr Tatjana Kostić
  • dr Nataša Tošić
  • dr Sonja Pavlović

Tel: +381 11 3976 445

Mob: +381 65 3976 445

Fax: +381 11 3975 808


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