Detection of numerical aberrations of chromosomes X, Y, 13, 18 and 21 in the spermatozoa by using FISH methods
This analysis gives precise information about sperm aneuploidy rate for chromosomes 13, 18, 21, X and Y. Studies shown that an elevated sperm aneuploidy rate is associated with a lower rate of pregnancy and higher rate of spontaneous abortions. The method employed for this analysis is fluorescent in situ hybridization (FISH). FISH is a molecular cytogenetic technique based on the hybridization between specific, fluorescently labeled DNA probe and complementary sequence in the biological sample.
For analysis is necessary fresh sperm sample delivered to the laboratory within 1h after ejaculation.
The analysis is also available for frozen sperm samples by prior arrangement with hospital that offers sperm freezing.
The samples are accepted only with prior scheduling.
Contact:
Danijela Drakulic, PhD
Laboratory for Human Molecular Genetics
tel. +381 11 3976 212
fax. +381 11 3975 808