Laboratory for Molecular Biology

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In the Laboratory for Molecular Biology we study molecular mechanisms that underlie cardiovascular, malignant, pulmonary and neuromuscular diseases. We primarily aim to elucidate basic physiological processes and etiopathological mechanisms in these diseases, with focus on translational potential of our research. Our main interests include:

  • Molecular mechanisms of various biological processes including haemostasis, inflammation, tissue remodeling and response to mechanical and oxidative stress.
  • Biological functions of selected molecules and their role in diseases of interest: MARP proteins, prothrombin, alpha 1-antitrypsin, TGFB1, SMAD4, CYP2C19 and VKORC1.
  • Influence of gene variants and environmental factors on the phenotype.
  • Identification and functional characterization of molecular markers.
  • Pharmacogenetics.
  • In vitro (primary and continuous cell lines) and in vivo (zebra fish) study of selected physiological and pathological interests.
  • Development of methods for non-invasive molecular diagnostics.

Laboratory for Molecular Biology successfully collaborates with a number of scientific research and health institutions in Serbia, as well as eminent foreign institutes. We are open to all types of cooperation.

Curent project
Selected publications
  • Dragicevic S, Kosnik M, Divac Rankov A, Rijavec M, Milosevic K, Korosec P, Skerbinjek Kavalar M, Nikolic A. The Variants in the 3' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma. Lung. 2018 Mar 29. doi: 10.1007/s00408-018-0113-y.
  • Divac Rankov A, Ljujic M, Petric M, Radojkovic D, Pesic M, Dinic J. Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells. Histochem Cell Biol. 2017;148(5):529-544.
  • Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V. Clinical and biochemical characterization of the Prothrombin Belgrade mutation in a large Serbian pedigree: new insights into antithrombin resistance mechanism. J Thromb Haemost. 2017;15(4):670-677.
  • Supic G, Zeljic K, Rankov AD, Kozomara R, Nikolic A, Radojkovic D, Magic Z. miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients. Clin Oral Investig 2017 Jun 14. doi: 10.1007/s00784-017-2126-y.
  • Backovic D, Ignjatovic S, Rakicevic L, Novkovic M, Kusic-Tisma J, Radojkovic D, Strugarevic E, Calija B, Radak D, Kovac M. Clopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Study. Curr Vasc Pharmacol. 2016;14(6):563-569.
  • Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S. Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles. Histochem Cell Biol. 2016;146(5):569-584.
  • Stankovic M, Kojic S, Djordjevic V, Tomovic A, Nagorni-Obradovic L, Petrovic-Stanojevic N, Mitic-Milikic M, Radojkovic D. Gene-environment interaction between the MMP9 C-1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease. Environ Mol Mutagen. 2016;57(6):447-454.
  • Kojic S, Nestorovic A, Rakicevic L, Protic O, Jasnic-Savovic J, Faulkner G, Radojkovic D. Cardiac transcription factor Nkx2.5 interacts with p53 and modulates its activity. Arch Biochem Biophys. 2015;569:45-53.
  • Nikolic A, Ristanovic M, Zivaljevic V, Rankov AD, Radojkovic D, Paunovic I. SMAD4 gene promoter mutations in patients with thyroid tumors. Exp Mol Pathol. 2015;99(1):100-103.
  • Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D. A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population.  J Thromb Haemost. 2013;11(10):1936-1939.

Vojvode Stepe 444a
P.O BOX 23
11010 Beograd, Srbija

Tel: +381 11 3976658
Faks: +381 11 3975808 


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