Gordana Nikčević

Full Research Professor
Laboratory for Molecular Biomedicine

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile: +381 65 397 64 45
Phone: +381 11 397 64 45
Fax:     +381 11 397 58 08
E-mail:  gordnik@imgge.bg.ac.rsgordnik7@gmail.com

EDUCATION

1998 - PhD in Biology, Faculty of Biology (FB), University of Belgrade (UB) (title of the thesis: "The effect of expression of the catalytic domain of myosin light chain kinase on the contractile properties of non-muscle cells")
1988 - M.Sc. in Biology, FB, UB
1984 - B.Sc. in Biology, FB, UB

RESEARCH EXPERIENCE

2016 -             Full Research Professor (Principal Research Fellow), IMGGE
2006 - 2016   Senior Research Associate, IMGGE
2000 - 2006 - Research Associate,IMGGE, UB
1993 - 2000 - Visiting Scientist, University of Illinois at Chicago, USA
1988 - 1993 - Research Assistant, IMGGE
1986 - 1988 - Research Trainee, Genetic Engineering Center, Belgrade

CAREER HISTORY

2014 - 2018 Lecturer on Faculty of Biology (FB), UB, at PhD course:
           Personalized Medicine and Pharmacogenomics
2008 - 2020 Lecturer on FB, UB, at PhD course:Methodological approaches in molecular biology
2007 - Lecturer on FB, UB, at PhD course:Molecular biology of the gene
2001 - 2006 - Deputy Director of the IMGGE, UB

OTHER ACTIVITIES

2017 -   Member of the Scientific Committee for Biology, Ministry of Education, Science and Technological Development of the Republic of Serbia
2013 - 2017 Chairman of the IMGGE, UB Scientific Board
2010 - Deputy Chairman of the IMGGE, UB Board

SELECTED PROJECTS 

Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation (SERBORDISinn), EU FP7-REGPOT-2012-2013-1, 316088, European Commission, 2013-2016. Scientific Coordinator/Assistant Coordinator

The Genes in Irritable Bowel Syndrome Research Network Europe (GENIEUR) - COST action BM1106, European Commission, 2012-2016. Management Committee Substitute for the Republic of Serbia

RESEARCH INTEREST

Molecular mechanisms involved in the regulation of expression of selected eukaryotic genes; molecular genetics and diagnosis of various rare diseases; genotype-phenotype correlation, including analysis of genetic variants relevant for the optimization of pharmacotherapy of inflammatory diseases. Application of animal mesenchymal stem cells from adipose tissue in regenerative medicine and studying the approaches to increase the therapeutic capacity of these cells through genetic modifications, by expressing specific transgenes whose products would promote regeneration of damaged tissues.

SELECTED PUBLICATIONS

  1. Nikcevic G, Srzentic Drazilov S, Karan Djurasevic T, Tosic N, Christos K. Kontos, Andreas Scorilas and Pavlovic S. Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells. Gene 2020, 750: 144723. https://pubmed.ncbi.nlm.nih.gov/32387119/
  1. Stankovic B, Dragasevic S, Klaassen K, Kotur N, Srzentic Drazilov S, Zukic B, Sokic Milutinovic A, Milovanovic T, Lukic S, Popovic D, Pavlovic S, Nikcevic G. Exploring inflammatory and apoptotic signatures in distinct Crohn's disease phenotypes: Way towards molecular stratification of patients and targeted therapy. Pathol Res Pract 2020, 216: 152945. https://pubmed.ncbi.nlm.nih.gov/32279918/
  1. Srzentić Dražilov S, Mrkovački J, Spasovski V, Fazlagić A, Pavlović S, Nikčević G. The use of canine mesenchymal stem cells for the autologous treatment of osteoarthritis. Acta Vet Hung 2018, 66: 376-389. https://pubmed.ncbi.nlm.nih.gov/30264620/
  1. Dragasevic S, Stankovic B, Milosavljevic T, Sokic-Milutinovic A, Lukic S, Alempijevic T, Zukic B, Kotur N, Nikcevic G, Pavlovic S, Popovic D. Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease. Eur J Gastroenterol Hepatol 2017, 29: 909-915. https://pubmed.ncbi.nlm.nih.gov/28452812/
  1. Gazouli M, Wouters MM, Kapur-Pojskić L, Bengtson MB, Friedman E, Nikčević G, Demetriou CA, Mulak A, Santos J, Niesler B. Lessons learned - resolving the enigma of genetic factors in IBS. Nat Rev Gastroenterol Hepatol 2016, 13: 77-87. https://pubmed.ncbi.nlm.nih.gov/26726033/
  1. Jasnic-Savovic J, Klajn A, Milivojevic M, Mojsin M, Nikcevic G. Human Embryonal Carcinoma Cells in Serum-free Conditions as an In Vitro Model System of Neural Differentiation. Altern Lab Anim 2015, 43: 9-18. https://pubmed.ncbi.nlm.nih.gov/25802994/
  1. Srzentić S, Nikčević G, Spasovski D, Baščarević Z, Živković Z, Terzic-Šupić Z, Matanović D, Djordjević V, Pavlović S, Spasovski V. Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease-Serbian experience. Eur J of Pediatr 2015, 174: 1085-1092. https://pubmed.ncbi.nlm.nih.gov/25754626/
  1. Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan – Djurasevic T, Srzentic S, Colovic M, Pavlovic S. The influence of novel transcriptional regulatory element in intron 14 on expression of Janus kinase 2 gene in myeloproliferative neoplasms. J Appl Genet 2013, 54: 21-26. http://www.ncbi.nlm.nih.gov/pubmed/23188718
  1. Kotur N, Stankovic B, Kassela K, Georgitsi M, Vicha A, Dokmanovic L, Janic D, Krstovski N, Klaassen K, Radmilovic M, Stojiljkovic M, Nikcevic G, Simeonidis A, Sivolapenko G, Pavlovic S, Patrinos GP, Zukic B. Six-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner. Pharmacogenomics 2012, 13: 283-295. http://www.ncbi.nlm.nih.gov/pubmed/22304581
  1. Nikčević G., Kovačević-Grujičić N., Mojsin M., Krstić A., Savić T., and Stevanović M. Regulation of the SOX3 Gene Expression by Retinoid Receptors. Physiol Res 2011, 60: S83-S91. https://pubmed.ncbi.nlm.nih.gov/21777018/
  1. Stojiljkovic M., Zukic B., Tosic N., Karan-Djurasevic T., Spasovski V., Nikcevic G. and Pavlovic S. Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron Mol Genet Metab 2010, 101: 81-83. http://www.ncbi.nlm.nih.gov/pubmed/20599406
  1. Nikčević G, Savić T, Kovačević-Grujičić N. and Stevanović M, Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. J Neurochem 2008, 107: 1206-1215. http://www.ncbi.nlm.nih.gov/pubmed/18786169
  1. Mojsin M, Grujicic KN, Nikcevic G, Krstic A, Savic T, Stevanovic M. Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 Neurosci Res 2006, 56: 409-418. http://www.ncbi.nlm.nih.gov/pubmed/17005281
  1. Nikčević, G., Kovačević-Grujičić, N. and Stevanović, M. Improved transfection efficiency of cultured human cells. Cell Biol Int 2003, 27: 735-737. http://www.ncbi.nlm.nih.gov/pubmed/12972278
  1. Nikčević, G., Perhonen, M., Boateng, S. and Russell, B. Translation is regulated via the 3’ untranslated region of a-myosin heavy chain mRNA by calcium but not by its localization. J Muscle Res Cell M 2000, 21: 599-607. http://www.ncbi.nlm.nih.gov/pubmed/11206137
  1. Nikčević, G., Heidkamp, M., Perhonen, M. and Russell, B. Mechanical activity in heart regulates translation of a-myosin heavy chain mRNA but not its localization. Am J Physiol-Heart Circ 1999, 276: H2013-H2019. http://www.ncbi.nlm.nih.gov/pubmed/10362682
  1. Hecht, G.A., Pestić, L., Nikčević, G., Koutsouris, A., Tripuraneni, J., Lorimer, D., Nowak, G., Guerriero, V., Elson, E. and de Lanerolle, P. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am J Physiol-Cell Physiol 1996, 271: C1678‑C1684 http://www.ncbi.nlm.nih.gov/pubmed/8944652
  1. Obara, K., Nikčević, G., Pestić, L., Nowak, G., Guerriero, V., Paul, R.J., Elson, E.L. and de Lanerolle, P. Fibroblast contractility without an increase in basal myosin light chain phosphorylation in wild type cells and cells expressing the catalytic domain of myosin light chain kinase. J Biol Chem 1995, 270: 18734‑18737 http://www.ncbi.nlm.nih.gov/pubmed/7642521
  1. Marjanović, J., Savković, S., Nikčević, G., Glišin, V., Ivanović, Z., Milenković, P. and Popović, Z. The disbalance of a‑ and b‑globins in anemic Belgrade rat red blood cells. Biochem Bioph Res Co 1994, 201: 115‑122. http://www.ncbi.nlm.nih.gov/pubmed/8198563
  1. Knežić, Z., Nikčević, G., Marjanović, J., Glišin, V. and Popović, Z. Constitutive interferon expression from retroviral vector. Antivir Res 1993, 22: 215‑221. http://www.ncbi.nlm.nih.gov/pubmed/8279813
 

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