ENG 
ЋИР 
LAT 
Research
In the Laboratory for Molecular Biology we study molecular mechanisms that underlie cardiovascular, malignant, pulmonary and neuromuscular diseases. We primarily aim to elucidate basic physiological processes and etiopathological mechanisms in these diseases, with focus on translational potential of our research. Our main interests include:
- Molecular mechanisms of various biological processes including haemostasis, inflammation, tissue remodeling and response to mechanical and oxidative stress.
- Biological functions of selected molecules and their role in diseases of interest: MARP proteins, prothrombin, alpha 1-antitrypsin, TGFB1, SMAD4, CYP2C19 and VKORC1.
- Influence of gene variants and environmental factors on the phenotype.
- Identification and functional characterization of molecular markers.
- Pharmacogenetics.
- In vitro (primary and continuous cell lines) and in vivo (zebra fish) study of selected physiological and pathological interests.
- Development of methods for non-invasive molecular diagnostics.
Laboratory for Molecular Biology successfully collaborates with a number of scientific research and health institutions in Serbia, as well as eminent foreign institutes. We are open to all types of cooperation.
Curent projects
- IMGGE work program for 2020
Ministry of Education, Science and Technological Development of the Republic of Serbia, 451-03-68/2020-14/200042, 2020
Principal Investigator: Dr Jelena Begovic, IMGGE
Participants from IMGGE: all employed researchers - SENSOGENE - Cancer biosensors based on gene regulatory elements
Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6052315, 2020-2022
Principal Investigator: Dr Aleksandra Nikolic, IMGGE
Participants from IMGGE: Dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic - LABLUNG - Mechanistic insight into the anti-inflammatory and antioxidative effects of lactic acid bacteria in in vitro models of chronic lung diseases
Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6066974, 2020-2022
Principal Investigator: Dr Marija Stankovic, IMGGЕ
Participants from IMGGE: Sofija Dunjic - A novel genotyping assay for root-knot nematode identification
Proof of Concept, Innovation Fund of the Republic of Serbia, 5116, 2020-2021
Principal Investigator: Dr Jelena Kusic Tisma, IMGGE - Application of fluorescent substrate for fast and specific detection of Staphylococcus aureus in milk
Proof of Concept, Innovation Fund of the Republic of Serbia, 5449, 2020-2021
Principal Investigator: Dr Maja Gvozdenov
Participants from IMGGE: Dr Valentina Djordjevic, dr Milan Kojic - New approach to thrombophilia screening
Proof of Concept, Innovation Fund of the Republic of Serbia, 5853, 2020-2021
Principal Investigator: Dr Valentina Djordjevic
Participants from IMGGE: Dr Maja Gvozdenov, Marija Cumbo, Sofija Dunjic - Pro-Belgrade - Could Prothrombin Belgrade mutation affect blood vessels? A new insight into thrombosis mechanism
Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, Science Fund of the Republic of Serbia, 6476784, 2020-2021
Principal Investigator: Dr Valentina Djordjevic, IMGGE
Participant from IMGGE: Sofija Dunjic - ProORC - Profiling ORC genetics and regulation in cancer
Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, Science Fund of the Republic of Serbia, 6504965, 2020-2021
Principal Investigator: Dr Jelena Kusic Tisma, IMGGE - Zebrafish as a model for asthma research - role of Wnt signalling in response to cigarette smoke
Research project within scientific and technological cooperation between Republic of Serbia and Federal Republic of Germany, 2019-2020
Principal Investigator: Aleksandra Divac Rankov, PhD, IMGGE
Participants from IMGGE: Dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic - Optimization (individualization) of rectal cancer treatment using predictive molecular genetic biomarkers
Serbian Academy of Sciences and Arts, F-20, 2013-
Principal Investigator: Prof. Zoran Krivokapic, Faculty of Medicine, University of Belgrade
Participants from IMGGE: Dr Dragica Radojkovic, dr Aleksandra Nikolic - Molecular basis of response to chemioradiotherapy in rectal cancer
Strategic project of Serbian Academy of Sciences and Arts, F-69, 2019-2022
Principal Investigator: Prof. Zoran Krivokapic, Faculty of Medicine, University of Belgrade
Participants from IMGGE: Dr Aleksandra Nikolic, dr Aleksandra Divac Rankov, dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic - Establishment of compatible institutional registers and network of counseling centers for hereditary gastrointestinal tumors
Research project within scientific and technological cooperation between Republic of Serbia and Republic of Croatia, 337-00-205/2019-09/34, 2019-2020
Principal Investigator: Prof. Zoran Krivokapic, Faculty of Medicine, University of Belgrade
Participant from IMGGE: Dr Aleksandra Nikolic - Gene regulation ensemble effort for the knowledge commons
COST Action CA15205, 2016-2020
Participant from IMGGE: Dr Valentina Djordjevic - Identifying Biomarkers Through Translational Research for Prevention and Stratification of Colorectal Cancer (TRANSCOLONCAN)
COST Action CA17118, 2018-2022
Participants from IMGGE: Dr Aleksandra Nikolic, dr Aleksandra Divac Rankov, dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic -
Alleviation of lung inflammation by probiotics
Proof of Concept, Innovation Fund of the Republic of Serbia, 5709, 2020-2021
Principal Investigator: Dr Katarina Veljovic
Participant from IMGGE: Dr Marija Stankovic
Selected publications
- The silence speaks, but we do not listen: synonymous c.1824C>T gene variant in the last exon of the prothrombin gene as a new prothrombotic risk factor
Pruner I, Farm M, Tomic B, Gvozdenov M, Kovac M, Miljic P, Soutari NMH, Antovic A, Radojkovic D, Antovic J, Djordjevic V
Clin Chem 2020;66(2):379-389 - Pharmacogenetics of Clopidogrel Therapy and Neurointerventional Procedures: We Need Precision Data for Precision Medicine
Rakicevic L, Nestorovic A
Clin Pharmacol Ther 2019;105(3):547-549 - Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise
Boskovic S, Marín-Juez R, Jasnic J, Reischauer S, El Sammak H, Kojic A, Faulkner G, Radojkovic D, Stainier DYR, Kojic S
PLoS One 2018;13(9):e0204312 - The Variants in the 3' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma
Dragicevic S, Kosnik M, Divac Rankov A, Rijavec M, Milosevic K, Korosec P, Skerbinjek Kavalar M, Nikolic A
Lung 2018;196(3):297-303 - Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel
Novkovic M, Matic D, Kusic-Tisma J, Antonijevic N, Radojkovic D, Rakicevic L
Eur J Clin Pharmacol 2018;74(4):443-451 - miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients
Supic G, Zeljic K, Rankov AD, Kozomara R, Nikolic A, Radojkovic D, Magic Z
Clin Oral Investig 2018;22(1):401-409 - Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells
Divac Rankov A, Ljujić M, Petrić M, Radojković D, Pešić M, Dinić J
Histochem Cell Biol 2017;148(5):529-544 - Clinical and biochemical characterization of the Prothrombin Belgrade mutation in a large Serbian pedigree: new insights into antithrombin resistance mechanism
Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V
J Thromb Haemost 2017;15(4):670-677. - Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles
Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S
Histochem Cell Biol 2016;146(5):569-584 - SMAD4 gene promoter mutations in patients with thyroid tumors
Nikolic A, Ristanovic M, Zivaljevic V, Rankov AD, Radojkovic D, Paunovic I
SMAD4 gene promoter mutations in patients with thyroid tumors
Exp Mol Pathol 2015;99(1):100-103
Contact
Vojvode Stepe 444a
P.O BOX 23
11010 Beograd, Srbija
Tel: +381 11 3976658
Faks: +381 11 3975808