The scientific goal of our group is to determine, starting from the molecular-genetic basis of a certain rare disease, which spectrum of variants is present in our country, and to establish whether there are any characteristic, frequent variants. If there are new variants, in that case we perform their characterization using in silico methods, or using different in vitro assays. We also study the correlation of genotype and phenotype. In cases where there is no expected correlation, we try to find genetic modifiers. Discovering new variants and genetic modifiers is important because they become potential targets for new therapeutics.
Our group has expertise in modeling rare diseases (application of CRISPR/Cas9 technology, etc.). The model systems we make are necessary for understanding the molecular basis of rare diseases and for new therapeutics testing. Furthermore, our goal is development of innovative therapeutics for rare diseases, those that specifically correct a variant (eg, pharmacological chaperones or antisense oligonucleotides) or those that target and correct some disturbed process in the cell.
European Network for Innovative Diagnosis and Treatment of Chronic Neutropenias (EuNet-INNOCHRON)
Science on the move - from lab to streets & school (ScienceSCool)
European Joint Programme on Rare Diseases
Analysis of the synergistic effect and therapeutic potential of small molecules in patients with recurrent pulmonary infections
EPICENTER - Employing High Performance Computing System for Building up a Germline Variant Calling Pipeline for Human Whole Genome Data
HEAD OF THE LABORATORY
ASSOCIATE RESEARCH PROFESSOR
ASSISTANT RESEARCH PROFESSOR
Head Office / Mailing address:
Vojvode Stepe 444a,
11042 Belgrade 152, Serbia
Tel: +381 11 3976445
Faks: +381 11 3975808
Head office / Mailing address: Vojvode Stepe 444a, 11042 Belgrade 152, Serbia / Web System By Emarket1ng.NET