Laboratory for Molecular Biology

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In the Laboratory for Molecular Biology we study molecular mechanisms that underlie cardiovascular, malignant, pulmonary and neuromuscular diseases. We primarily aim to elucidate basic physiological processes and etiopathological mechanisms in these diseases, with focus on translational potential of our research. Our main interests include:

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• Molecular mechanisms of various biological processes including haemostasis, inflammation, tissue remodeling and response to mechanical and oxidative stress.
• Biological functions of selected molecules and their role in diseases of interest: MARP proteins, prothrombin, alpha 1-antitrypsin, TGFB1, SMAD4, CYP2C19 and VKORC1.
• Influence of gene variants and environmental factors on the phenotype.
• Identification and functional characterization of molecular markers.
• Pharmacogenetics.
• In vitro (primary and continuous cell lines) and in vivo (zebra fish) study of selected physiological and pathological interests.
• Development of methods for non-invasive molecular diagnostics.

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Laboratory for Molecular Biology successfully collaborates with a number of scientific research and health institutions in Serbia, as well as eminent foreign institutes. We are open to all types of cooperation.

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• IMGGE work program for 2022
  Ministry of Education, Science and Technological Development of the Republic of Serbia, 451-03-68/2022-14/200042, 2022
  Principal Investigator: Dr Jelena Begovic, IMGGE
  Participants from IMGGE: all employed researchers
• ZEBARR - Zebrafish ankrd1a as a common player in heart regeneration and skeletal muscle repair - a new prospect for unlocking regenerative potential of human heart
  Program IDEAS, Science Fund of the Republic of Serbia, 7739807, 2021-2024
  Principal Investigator: Dr Snezana Kojic, IMGGE
  Participants from IMGGE: Dr Jovana Jasnic, dr Mirjana Novkovic, dr Marko Vasic, dr Srdjan Boskovic, Emilija Milosevic
• SENSOGENE - Cancer biosensors based on gene regulatory elements
  Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6052315, 2020-2022
  Principal Investigator: Dr Aleksandra Nikolic, IMGGE
  Participants from IMGGE: Dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic
• LABLUNG - Mechanistic insight into the anti-inflammatory and antioxidative effects of lactic acid bacteria in in vitro models of chronic lung diseases
  Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6066974, 2020-2022
  Principal Investigator: Dr Marija Stankovic, IMGGЕ
  Participants from IMGGE: Sofija Dunjic
• Application of fluorescent substrate for fast and specific detection of Staphylococcus aureus in milk
  Proof of Concept, Innovation Fund of the Republic of Serbia, 5449, 2020-2022
  Principal Investigator: Dr Maja Gvozdenov
  Participants from IMGGE: Dr Valentina Djordjevic
• New approach to thrombophilia screening
  Proof of Concept, Innovation Fund of the Republic of Serbia, 5853, 2020-2021
  Principal Investigator: Dr Valentina Djordjevic
  Participants from IMGGE: Dr Maja Gvozdenov, Marija Cumbo, Sofija Dunjic
• Evaluation of AKR1B1 expression in the stromal compartment of colorectal tumors
  Research project within the scientific and technological cooperation between the Ministry of Education, Science and Technological Development of the Republic of Serbia and the Council for Scientific and Technological Research of Turkey, 2021-2024
  Principal Investigator: Dr Aleksandra Nikolic
  Participants from IMGGE: Dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic
• Pro-Belgrade - Could Prothrombin Belgrade mutation affect blood vessels? A new insight into thrombosis mechanism
  Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, Science Fund of the Republic of Serbia, 6476784, 2020-2022
  Principal Investigator: Dr Valentina Djordjevic, IMGGE
  Participant from IMGGE: Sofija Dunjic
• ProORC - Profiling ORC genetics and regulation in cancer
  Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, Science Fund of the Republic of Serbia, 6504965, 2020-2021
  Principal Investigator: Dr Jelena Kusic Tisma, IMGGE
• GENIUS - Genetic and environmental influences on psychological adaptation of children and adults
  Program IDEAS, Science Fund of the Republic of Serbia, 7744418, 2021-2024|
  Principal Investigator: Dr Snezana Smederevac, Faculty of Philosophy, University of Novi Sad
  Participant from IMGGE: Dr Jelena Kusic-Tisma
• Optimization (individualization) of rectal cancer treatment using predictive molecular genetic biomarkers
  Serbian Academy of Sciences and Arts, F-20, 2013-
  Principal Investigator: Prof. Zoran Krivokapic, Faculty of Medicine, University of Belgrade
  Participants from IMGGE: Dr Dragica Radojkovic, dr Aleksandra Nikolic
• Molecular basis of response to chemioradiotherapy in rectal cancer
  Strategic project of Serbian Academy of Sciences and Arts, F-69, 2019-2022
  Principal Investigator: Prof. Zoran Krivokapic, Faculty of Medicine, University of Belgrade
  Participants from IMGGE: Dr Aleksandra Nikolic, dr Aleksandra Divac Rankov, dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic
• Identifying Biomarkers Through Translational Research for Prevention and Stratification of Colorectal Cancer (TRANSCOLONCAN)
  COST Action CA17118, 2018-2022
  Participants from IMGGE: Dr Aleksandra Nikolic, dr Aleksandra Divac Rankov, dr Sandra Dragicevic, Jovana Despotovic, Tamara Babic
• Alleviation of lung inflammation by probiotics
  Proof of Concept, Innovation Fund of the Republic of Serbia, 5709, 2020-2022
  Principal Investigator: Dr Katarina Veljovic
  Participant from IMGGE: Dr Marija Stankovic
• Examination of possible applications of direct thrombin inhibitors in the therapy of colon cancer
  Program "Pokreni se za nauku", Phillip Morris Company, 2020-2021
  Principal Investigator: Dr Branko Tomic, IMGGE
  Participants from IMGGE: Dr Maja Gvozdenov, Marija Cumbo, Srdjan Boskovic
• Tiny creatures reign in our kitchen drain
  Society for Applied Microbiology, 2022-2023
  Principal Investigator: Dr Sanja Jeremic, IMGGE
  Participant from IMGGE: Dr Aleksandra Nikolic

• Science on the move - from lab to streets & school (ScienceSCool)
  European Comission, 101061631, 2022-2023
  Principal Investigator: Dr Biljana Sljukic Paunkovic, Faculty of Physical Chemistry, University of Belgrade
  Participants from IMGGE: Dr Aleksandra Nikolic, dr Sandra Dragicevic, dr Aleksandra Divac Rankov, Tamara Babic

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• Effects of Chemotherapy for Metastatic Colorectal Cancer on the TGF-β Signaling and Related miRNAs hsa-miR-17-5p, hsa-miR-21-5p and hsa-miR-93-5p
  Despotovic J, Dragicevic S, Nikolic A
  Cell Biochem Biophys. 2021 doi 10.1007/s12013-021-00980-3
• Bacterial nanocellulose as a scaffold for in vitro cell migration assay
  Ugrin M, Dinic J, Jeremic S, Dragicevic S, Banovic Djeri B, Nikolic A
  Nanomaterials. 2021;11(9):2322.
• Detection of somatic mutations with ddPCR from liquid biopsy of colorectal cancer patients
  Prosenc Zmrzljak U, Kosir R, Krivokapic Z, Radojkovic D, Nikolic A
  Genes 2021;12(2):289.
• The silence speaks, but we do not listen: synonymous c.1824C>T gene variant in the last exon of the prothrombin gene as a new prothrombotic risk factor
  Pruner I, Farm M, Tomic B, Gvozdenov M, Kovac M, Miljic P, Soutari NMH, Antovic A, Radojkovic D, Antovic J, Djordjevic V
  Clin Chem 2020;66(2):379-389
• Pharmacogenetics of Clopidogrel Therapy and Neurointerventional Procedures: We Need Precision Data for Precision Medicine
  Rakicevic L, Nestorovic A
  Clin Pharmacol Ther 2019;105(3):547-549
• Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise
  Boskovic S, Marín-Juez R, Jasnic J, Reischauer S, El Sammak H, Kojic A, Faulkner G, Radojkovic D, Stainier DYR, Kojic S
  PLoS One 2018;13(9):e0204312
• Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel
  Novkovic M, Matic D, Kusic-Tisma J, Antonijevic N, Radojkovic D, Rakicevic L
  Eur J Clin Pharmacol 2018;74(4):443-451
• Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells
  Divac Rankov A, Ljujić M, Petrić M, Radojković D, Pešić M, Dinić J
  Histochem Cell Biol 2017;148(5):529-544
• Clinical and biochemical characterization of the Prothrombin Belgrade mutation in a large Serbian pedigree: new insights into antithrombin resistance mechanism
  Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V
  J Thromb Haemost 2017;15(4):670-677.
• Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles
  Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S
  Histochem Cell Biol 2016;146(5):569-584

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Vojvode Stepe 444a
P.O BOX 23
11010 Beograd, Srbija

Tel: +381 11 3976658
Faks: +381 11 3975808

labmolbio@imgge.bg.ac.rs 

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