Laboratory for Human Molecular Genetics

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Research
Laboratory for Human Molecular Genetics (LHMG) has a long standing expertise in studying the expression of human SOX genes and the roles of transcriptional factors, signaling pathways and epigenetic mechanisms in the regulation of their activities. In addition, we investigate the effects of the modulations of SOX genes expression on the processes of in vitro neurogenesis and acquisition of malignant phenotype.

LHMG is studying mitochondrial DNA diversity of contemporary Serbian population which represents a foundation for further comparative analysis of ancient populations that inhabited the region of Serbia.

One of our research interests is focused on testing the potential antitumor and neuroprotective effects of bioactive and synthetic compounds. Therapeutic potential is evaluated by applying in vitro tests for cell viability, intracellular stress, proliferation, apoptosis, adhesion and migration.

LHMG provides molecular diagnostics of microdeletion syndromes using Fluorescent in situ Hybridization (FISH), analysis of sperm DNA fragmentation which complements the existing protocols for sterility therapy, as well as genetic markers assisted selection for economic trait loci in domestic animals.

LHMG is modern well-equipped laboratory with highly competent researchers in the field of human molecular genetics. LHMG associates actively participate in theoretical education and practical training of students at the Faculty of Biology, University of Belgrade.

Selected publications
  • Topalovic V, Krstic A, Schwirtlich M, Dolfini D, Mantovani R, Stevanovic M, Mojsin M. Epigenetic regulation of human SOX3 gene expression during early phases of neuraldifferentiation of NT2/D1 cells. PloS One. 2017;12(9): e0184099.
  • Stojkovic DS, Kovacevic-Grujicic N, Reis FS, Davidovic S, Barros L, Popovic J, Petrovic I, Pavic A, Glamoclija J, Ciric A, Stevanovic M, Ferreira I, Sokovic M. Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. Lwt-Food Sci Technol. 2017;79:454-462.
  • Stanisavljevic D, Petrovic I, Vukovic V, Schwirtlich M, Gredic M, Stevanovic M, Popovic J. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PloS One. 2017;12(9): e0184686.
  • Rakonjac M, Cuturilo G, Stevanovic M, Jelicic L, Subotic M, Jovanovic I, Drakulic D. Differences in speech and language abilities between children with 22q11.2 deletion syndrome and children with phenotypic features of 22q11.2 deletion syndrome but without microdeletion. Res Dev Disabil. 2016;55:322-329.
  • Cuturilo G, Drakulic D, Jovanovic I, Krstic A, Djukic M, Skoric D, Mijovic M, Stefanovic I, Milivojevic M, Stevanovic M. Improving the Diagnosis of Children with 22q11.2 Deletion Syndrome: A Single-center Experience from Serbia. Indian pediatrics. 2016;53(9):786-789.
  • Petrovic I, Milivojevic M, Popovic J, Schwirtlich M, Rankovic B, Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PloS One. 2015;10(11):e0143591.
  • Mojsin M, Topalovic V, Vicentic JM, Schwirtlich M, Stanisavljevic D, Drakulic D, Stevanovic M. Crosstalk between SOXB1 proteins and WNT/beta-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 2015;144(5):429-441.
  • Drakulic D, Vicentic JM, Schwirtlich M, Tosic J, Krstic A, Klajn A, Stevanovic M. The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. An Acad Bras Cienc. 2015;87(1):389-404.
  • Davidovic S, Malyarchuk B, Aleksic JM, Derenko M, Topalovic V, Litvinov A, Stevanovic M, Kovacevic-Grujicic N. Mitochondrial DNA perspective of Serbian genetic diversity. Am J Phys Anthropol. 2015;156(3):449-465.
  • Popovic J, Stanisavljevic D, Schwirtlich M, Klajn A, Marjanovic J, Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. PloS One. 2014;9(3):e91852.
Contact

Vojvode Stepe 444a
P.O BOX 23
11010 Belgarde, Serbia

Tel: +381 11 3976212, +381 65 3976212
Faks: +381 11 3975808

hmgbox@imgge.bg.ac.rs 

RESEARCHERS

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