Laboratory for Molecular Biology is the first laboratory in our country which in 1998 introduced molecular diagnostics of thrombophilia. The basic thrombophila diagnostic panel includes: FV Leiden, FII G20210A and MTHFR C677T mutations. Indications for testing are: personal or family history of venous thrombosis, pulmonary embolism, APC resistance, cerebral-vein thrombosis and peripheral vascular disease. These mutations also represent significant risk factors for unexplained recurrent miscarriages. In the molecular diagnostics of thrombophilia, Laboratory of Molecular Biology is the only one in our country that performs detection of 4G/5G polymorphism in the gene for plasminogen activator inhibitor-1 (PAI-1). Testing for the presence of this polymorphism is indicated in patients with arterial and venous thrombosis, coronary artery disease, stroke and unexplained recurrent miscarriages. Since 2004, our laboratory has participated in the European Quality Control Program organized by DGKL, Reference Institute for Bioanalytics.

CONTACT: Valentina Đorđević, MSc, Marija Stanković, MSc,

Dragica Radojkovic, PhD

TEL: ++ 381 11 3976 658

FAX: ++ 381 11 3975 808

e-mail: qwert@eunet.rs